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Gene Targeting

Known as: Targetings, Gene, Targeting, Gene, Gene Targetings 
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Monkeys serve as important model species for studying human diseases and developing therapeutic strategies, yet the application… Expand
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Highly Cited
2011
Highly Cited
2011
699 To the Editor: Studies of targeted gene modifications are of great interest in basic research as well as for clinical and… Expand
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Highly Cited
2007
Highly Cited
2007
We describe a rapid method for the production of fusion PCR products that can be used, generally without band purification, to… Expand
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Highly Cited
2004
Highly Cited
2004
Conditional mutagenesis in mice has recently been made possible through the combination of gene targeting techniques and site… Expand
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Highly Cited
2003
Highly Cited
2003
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique… Expand
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Highly Cited
2003
Highly Cited
2003
Correction of gene defects in human somatic cells by targeting as has been used in murine embryonic stem cells (1, 2) has been… Expand
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Highly Cited
1998
Highly Cited
1998
We describe a straightforward PCR-based approach to the deletion, tagging, and overexpression of genes in their normal… Expand
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Highly Cited
1995
Highly Cited
1995
A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an… Expand
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Highly Cited
1994
Highly Cited
1994
Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal… Expand
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Highly Cited
1987
Highly Cited
1987
We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem… Expand
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