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Gene Targeting

Known as: Targetings, Gene, Targeting, Gene, Gene Targetings 
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as… 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
We describe a rapid method for the production of fusion PCR products that can be used, generally without band purification, to… 
Highly Cited
2003
Highly Cited
2003
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique… 
Highly Cited
2003
Highly Cited
2003
Correction of gene defects in human somatic cells by targeting as has been used in murine embryonic stem cells (1, 2) has been… 
Highly Cited
1999
Highly Cited
1999
Conditional mutagenesis in mice has recently been made possible through the combination of gene targeting techniques and site… 
Review
1998
Review
1998
Molecular techniques now allow the design of precise genetic modifications in the mouse. Not only can defined nucleotide changes… 
Highly Cited
1995
Highly Cited
1995
A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an… 
Highly Cited
1994
Highly Cited
1994
Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal… 
Highly Cited
1992
Highly Cited
1992
We have inactivated the endogenous apolipoprotein E (apoE) gene by using gene targeting in mouse embryonic stem (ES) cells. Two… 
Highly Cited
1992
Highly Cited
1992
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known…