Gene Targeting

Known as: Targetings, Gene, Targeting, Gene, Gene Targetings 
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
0204019882018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Homologous recombination-based gene targeting using Mus musculus embryonic stem cells has greatly impacted biomedical research… (More)
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Highly Cited
2007
Highly Cited
2007
Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses. However, their biological roles are mostly… (More)
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Highly Cited
2006
Highly Cited
2006
This report describes high-frequency germline gene targeting at two genomic loci in Drosophila melanogaster, y and ry. In the… (More)
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Highly Cited
2006
Highly Cited
2006
Gene targeting by homologous recombination is a powerful method to manipulate the genome precisely and could be exploited to… (More)
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Highly Cited
2005
Highly Cited
2005
Inducing destruction of specific mRNA using small interfering RNA (siRNA) is a powerful tool in analysis of protein function, but… (More)
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Highly Cited
2003
Highly Cited
2003
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique… (More)
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Highly Cited
2003
Highly Cited
2003
Gene targeting is the in situ manipulation of the sequence of an endogenous gene by the introduction of homologous exogenous DNA… (More)
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Highly Cited
2002
Highly Cited
2002
Modification of genes through homologous recombination, termed gene targeting, is the most direct method to characterize gene… (More)
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Highly Cited
1998
Highly Cited
1998
Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are quite large (approximately 100-300 nm… (More)
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Highly Cited
1988
Highly Cited
1988
Although the generation of transgenic plants is now routine, the integration of foreign genetic information has so far been at… (More)
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