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Gene Targeting

Known as: Targetings, Gene, Targeting, Gene, Gene Targetings 
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as… 
National Institutes of Health

Related topics

Related topics

10 relations
Animals, Genetically ModifiedAnimals, TransgenicGene ExpressionGene Knockout Techniques

Narrower (1)

Homologous Recombination

Broader (1)

genetic manipulation

Papers overview

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Highly Cited
2008
Highly Cited
2008
Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Calpha activation in cancer cells.
We succeeded in cancer cell specific gene expression by using a polyplex responsive to protein kinase Calpha, which is activated… 
Highly Cited
2003
Highly Cited
2003
Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes
Homologous recombination in Escherichia coli simplifies the generation of gene targeting constructs for transduction into mouse… 
Review
2000
Review
2000
Suppression of Gene Expression by Targeted Disruption of Messenger RNA: Available Options and Current Strategies
At least three different approaches may be used for gene targeting including: A) gene knockout by homologous recombination; B… 
Highly Cited
1999
Highly Cited
1999
T-DNA from Agrobacterium tumefaciens as an efficient tool for gene targeting in Kluyveromyces lactis
Abstract The soil bacterium Agrobacterium tumefaciens can transfer a part of its tumour-inducing (Ti) plasmid, the T-DNA, to… 
Review
1995
Review
1995
Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System
A possible role of the plasminogen/plasmin or fibrinolytic system in several biological processes has been implied from… 
Highly Cited
1994
Highly Cited
1994
Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
The mouse alpha-lactalbumin gene has been replaced with the human gene by two consecutive rounds of gene targeting in… 
Highly Cited
1994
Highly Cited
1994
Gene targeting in normal somatic cells: inactivation of the interferon–γ receptor in myoblasts
Gene targeting in somatic cells represents a potentially powerful method for gene therapy, yet with the exception of pluripotent… 
Highly Cited
1993
Highly Cited
1993
Simple and efficient production of embryonic stem cell-embryo chimeras by coculture.
A method for the production of embryonic stem (ES) cell-embryo chimeras was developed that involves the simple coculture of eight… 
Highly Cited
1991
Highly Cited
1991
Cotransformation and gene targeting in mouse embryonic stem cells
We have investigated cotransformation in mammalian cells and its potential for identifying cells that have been modified by gene… 
Highly Cited
1991
Highly Cited
1991
Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.
The alpha i2 subunit of the inhibitory heterotrimeric guanine nucleotide-binding proteins is highly conserved in mammals and is… 
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