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Gene Targeting

Known as: Targetings, Gene, Targeting, Gene, Gene Targetings 
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as… 
National Institutes of Health

Related topics

Related topics

10 relations
Animals, Genetically ModifiedAnimals, TransgenicGene ExpressionGene Knockout Techniques

Narrower (1)

Homologous Recombination

Broader (1)

genetic manipulation

Papers overview

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2001
2001
Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart
Abnormalities in cardiac gap junction expression have been postulated to contribute to arrhythmias and ventricular dysfunction… 
Highly Cited
1999
Highly Cited
1999
T-DNA from Agrobacterium tumefaciens as an efficient tool for gene targeting in Kluyveromyces lactis
Abstract The soil bacterium Agrobacterium tumefaciens can transfer a part of its tumour-inducing (Ti) plasmid, the T-DNA, to… 
Review
1999
Review
1999
Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
The molecular basis of lymphoid organogenesis has recently been elucidated using gene-targeted mice. Mice deficient in… 
1999
1999
A murine model for juvenile NCL: gene targeting of mouse Cln3.
JNCL is a neurodegenerative disease of childhood caused by mutations in the CLN3 gene. A mouse model for JNCL was created by… 
1995
1995
The effect of target site transcription on gene targeting in human cells in vitro.
We evaluate the effect of target site transcription on gene targeting in cultured human fibrosarcoma cells. A number of cell… 
Highly Cited
1994
Highly Cited
1994
Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
The mouse alpha-lactalbumin gene has been replaced with the human gene by two consecutive rounds of gene targeting in… 
1994
1994
Homology-associated nonhomologous recombination in mammalian gene targeting.
Nonhomologous (illegitimate) recombination of DNA underlies many changes in the genome. It involves no or little homology between… 
1992
1992
Embryonic stem cells as a model for cardiogenesis.
Highly Cited
1991
Highly Cited
1991
Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.
The alpha i2 subunit of the inhibitory heterotrimeric guanine nucleotide-binding proteins is highly conserved in mammals and is… 
Review
1989
Review
1989
Embryonic stem cell culture and gene targeting in transgenic mice.
Genetically altered embryonic stem (ES) cells re-injected into mouse blastocysts take part in the formation of all tissues… 
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