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Gene Targeting
Known as:
Targetings, Gene
, Targeting, Gene
, Gene Targetings
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The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as…
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National Institutes of Health
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Related topics
Related topics
10 relations
Animals, Genetically Modified
Animals, Transgenic
Gene Expression
Gene Knockout Techniques
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Narrower (1)
Homologous Recombination
Broader (1)
genetic manipulation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Fusion PCR and gene targeting in Aspergillus nidulans
Edyta Szewczyk
,
Tania Nayak
,
+5 authors
B. Oakley
Nature Protocols
2006
Corpus ID: 24963337
We describe a rapid method for the production of fusion PCR products that can be used, generally without band purification, to…
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Highly Cited
2003
Highly Cited
2003
Enhancing Gene Targeting with Designed Zinc Finger Nucleases
M. Bibikova
,
Kelly J. Beumer
,
J. Trautman
,
D. Carroll
Science
2003
Corpus ID: 42087531
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique…
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Highly Cited
2003
Highly Cited
2003
Chimeric Nucleases Stimulate Gene Targeting in Human Cells
M. Porteus
,
D. Baltimore
Science
2003
Corpus ID: 34460337
Correction of gene defects in human somatic cells by targeting as has been used in murine embryonic stem cells (1, 2) has been…
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Highly Cited
1999
Highly Cited
1999
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
B. Clausen
,
C. Burkhardt
,
W. Reith
,
R. Renkawitz
,
I. Förster
Transgenic research
1999
Corpus ID: 25373599
Conditional mutagenesis in mice has recently been made possible through the combination of gene targeting techniques and site…
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Review
1998
Review
1998
Inducible gene targeting in mice using the Cre/lox system.
B. Sauer
Methods
1998
Corpus ID: 5547150
Molecular techniques now allow the design of precise genetic modifications in the mouse. Not only can defined nucleotide changes…
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Highly Cited
1995
Highly Cited
1995
Inducible gene targeting in mice
Reinhard Kuehn
,
F. Schwenk
,
M. Aguet
,
K. Rajewsky
Science
1995
Corpus ID: 41004156
A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an…
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Highly Cited
1994
Highly Cited
1994
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.
H. Gu
,
J. Marth
,
P. Orban
,
H. Mossmann
,
K. Rajewsky
Science
1994
Corpus ID: 19838380
Deletion of the promoter and the first exon of the DNA polymerase beta gene (pol beta) in the mouse germ line results in a lethal…
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Highly Cited
1992
Highly Cited
1992
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.
J. Piedrahita
,
Sunny H. Zhang
,
J. Hagaman
,
P. Oliver
,
N. Maeda
Proceedings of the National Academy of Sciences…
1992
Corpus ID: 25390304
We have inactivated the endogenous apolipoprotein E (apoE) gene by using gene targeting in mouse embryonic stem (ES) cells. Two…
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Highly Cited
1992
Highly Cited
1992
An Animal Model for Cystic Fibrosis Made by Gene Targeting
J. Snouwaert
,
K. Brigman
,
+4 authors
B. Koller
Science
1992
Corpus ID: 27676852
Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known…
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Highly Cited
1987
Highly Cited
1987
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
K. Thomas
,
M. Capecchi
Cell
1987
Corpus ID: 31961262
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