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Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.
The results demonstrate the pivotal role of beta-catenin in morphogenetic processes during brain and craniofacial development, and analysis of neural tube explants shows that (beta- catenin is efficiently deleted in migrating neural crest cell precursors), suggests that removal of Beta-Catenin affects Neural crest cell survival and/or differentiation. Expand
The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium.
- T. Doetschman, H. Eistetter, M. Katz, W. Schmidt, R. Kemler
- Biology, Medicine
- Journal of embryology and experimental morphology
- 1 June 1985
The in vitro developmental potential of mouse blastocyst-derived embryonic stem cell lines and the consistency with which the cells express this potential are presented as aspects which open up new approaches to the investigation of embryogenesis. Expand
Wnt3a plays a major role in the segmentation clock controlling somitogenesis.
The segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates. Expand
β‐catenin is a target for the ubiquitin–proteasome pathway
It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin. Expand
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
The characterization of 102, 88 and 80 kd proteins provides a first molecular basis for a possible cytoplasmic anchorage of uvomorulin to the cytoskeleton and proposes the nomenclature of catenin alpha, beta and gamma respectively. Expand
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge.
Wnt3, which is expressed ubiquitously throughout the limb ectoderm, is essential for normal limb development and plays a critical role in the establishment of the AER, and it is demonstrated that Wnt/beta-catenin signaling lies upstream of the Bmp signaling pathway in establishment ofThe AER and regulation of the dorsoventral polarity of the limb. Expand
beta-catenin is a target for the ubiquitin-proteasome pathway.
It is shown that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of Beta-Catenin. Expand
Nuclear localization of β-catenin by interaction with transcription factor LEF-1
- O. Huber, R. Korn, J. Mclaughlin, M. Ohsugi, B. Herrmann, R. Kemler
- Medicine, Biology
- Mechanisms of Development
- 1 September 1996
It is demonstrated that beta-catenin binds to the HMG-type transcription factor lymphoid enhancer factor-1 (LEF-1), resulting in a nuclear translocation of beta-Catenin both in cultured mouse cells and after ectopic expression of LEF- 1 in two-cell mouse embryos. Expand
Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.
- M. Ozawa, M. Ringwald, R. Kemler
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 June 1990
The results suggest thatCatenin alpha plays a key role in the association with actin filaments, whereas catenin beta binds more directly to the cytoplasmic region of uvomorulin. Expand
Identification of a Wnt/Dvl/β-Catenin → Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development
The bicoid-related transcription factor Pitx2 is rapidly induced by the Wnt/Dvl/beta-catenin pathway and is required for effective cell-type-specific proliferation by directly activating specific growth-regulating genes. Expand