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BRCA2 gene

Known as: BRCC2, BRCA2 Genes, BRCA2 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast… 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal… 
Highly Cited
2005
Highly Cited
2005
Poly(ADP-ribose) polymerase (PARP1) facilitates DNA repair by binding to DNA breaks and attracting DNA repair proteins to the… 
Highly Cited
2003
Highly Cited
2003
Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor… 
Highly Cited
2003
Highly Cited
2003
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… 
Highly Cited
2002
Highly Cited
2002
Fanconi anemia (FA) is a rare autosomal recessive cancer susceptibility disorder characterized by cellular hypersensitivity to… 
Highly Cited
1999
Highly Cited
1999
  • H. Olsson
  • Journal of the National Cancer Institute
  • 1999
  • Corpus ID: 31162194
BACKGROUND Carriers of germline mutations in the BRCA2 gene are known to be at high risk of breast and ovarian cancers, but the… 
Highly Cited
1998
Highly Cited
1998
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families… 
Highly Cited
1996
Highly Cited
1996
Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest… 
Highly Cited
1995
Highly Cited
1995
IN Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer… 
Highly Cited
1994
Highly Cited
1994
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant…