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BRCA2 gene

Known as: BRCC2, BRCA2 Genes, BRCA2 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure (BMF), congenital defects, inability to… Expand
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Review
2019
Review
2019
BACKGROUND Poly ADP-ribose polymerase (PARP) inhibitors, such as olaparib, are being explored as a treatment option for… Expand
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Review
2018
Review
2018
BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of… Expand
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Review
2018
Review
2018
Purpose The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well… Expand
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Review
2018
Review
2018
Background Investigations of the associations with colorectal cancer have yielded conflicting results. The aim of our study was… Expand
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Highly Cited
2003
Highly Cited
2003
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… Expand
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Highly Cited
1999
Highly Cited
1999
  • H. Olsson
  • Journal of the National Cancer Institute
  • 1999
  • Corpus ID: 31162194
BACKGROUND Carriers of germline mutations in the BRCA2 gene are known to be at high risk of breast and ovarian cancers, but the… Expand
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Highly Cited
1996
Highly Cited
1996
Breast carcinoma is the most common malignancy among women in developed countries. Because family history remains the strongest… Expand
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Highly Cited
1995
Highly Cited
1995
IN Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer… Expand
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Highly Cited
1994
Highly Cited
1994
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant… Expand
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