BRCA2 gene

Known as: BRCC2, BRCA2 Genes, BRCA2 
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
PALB2 interacts with BRCA2, and biallelic mutations in PALB2 (also known as FANCN), similar to biallelic BRCA2 mutations, cause… (More)
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Highly Cited
2007
Highly Cited
2007
This corrects the article DOI: 10.1038/nature03443 
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Highly Cited
2003
Highly Cited
2003
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… (More)
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Highly Cited
2003
Highly Cited
2003
Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor… (More)
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Highly Cited
2001
Highly Cited
2001
Inheritance of one defective BRCA2 allele predisposes humans to breast cancer. To establish a mouse model for BRCA2-associated… (More)
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Highly Cited
2001
Highly Cited
2001
The BRCA2 tumor suppressor has been implicated in the maintenance of chromosomal stability through a function in DNA repair. In… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Carriers of germ-line mutations in BRCA1 and BRCA2 from families at high risk for cancer have been estimated to have… (More)
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Highly Cited
1995
Highly Cited
1995
IN Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer… (More)
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Highly Cited
1994
Highly Cited
1994
A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant… (More)
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