BRCA2 Gene Mutation

Known as: BRCA2 Mutation, Mutation of the BRCA2 Gene 
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2017
05101519982017

Papers overview

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2017
2017
Importance The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates… (More)
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2017
2017
Background Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook a… (More)
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2017
2017
Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for… (More)
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2016
2016
IMPORTANCE BRCA testing is recommended for young women diagnosed as having breast cancer, but little is known about decisions… (More)
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2014
2014
BACKGROUND Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a… (More)
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2013
2013
Recommendations for women with a deleterious BRCA1 or BRCA2 gene mutation include complex medical approaches related to cancer… (More)
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2012
2012
Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 mutation carriers effectively reduces ovarian cancer risk… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Risk-reducing salpingo-oophorectomy (RRSO) is widely used by carriers of BRCA1 or BRCA2 (BRCA1/2) mutations to reduce… (More)
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Highly Cited
2006
Highly Cited
2006
CONTEXT Women with BRCA1 or BRCA2 mutation are often advised to undergo preventive oophorectomy. The effectiveness of this… (More)
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2005
2005
We conducted an exploratory, qualitative study investigating experiences of women who had developed breast cancer under the age… (More)
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