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BRCA2 Gene Mutation
Known as:
BRCA2 Mutation
, Mutation of the BRCA2 Gene
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small…
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National Institutes of Health
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Related topics
Related topics
12 relations
BRCA2 gene
Colloid Carcinoma of the Pancreas
Hereditary Male Breast Carcinoma
Hereditary Prostate Carcinoma
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast…
M. Robson
,
N. Tung
,
+11 authors
S. Domchek
Annals of oncology : official journal of the…
2019
Corpus ID: 210933920
BACKGROUND In the OlympiAD study, olaparib was shown to improve progression-free survival compared with chemotherapy treatment of…
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Highly Cited
2019
Highly Cited
2019
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast…
M. Robson
,
N. Tung
,
+11 authors
S. Domchek
Annals of oncology : official journal of the…
2019
Corpus ID: 59342503
Abstract Background In the OlympiAD study, olaparib was shown to improve progression-free survival compared with chemotherapy…
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2017
2017
An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity
Monique Sajjad
,
M. Fradley
,
+4 authors
R. Ismail-Khan
Genes
2017
Corpus ID: 14730487
Anthracycline-based cardiotoxicity is concerning for women with breast cancer and portends a dose-dependent risk of developing…
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2015
2015
miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers
S. Vos
,
F. Vesuna
,
V. Raman
,
P. V. van Diest
,
P. van der Groep
Oncotarget
2015
Corpus ID: 2678249
miRNA deregulation has been found to promote carcinogenesis. Little is known about miRNA deregulation in hereditary breast tumors…
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2014
2014
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
P. Peterlongo
,
J. Chang-Claude
,
+198 authors
E. Friedman
Cancer Epidemiology, Biomarkers & Prevention
2014
Corpus ID: 23215451
Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The…
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2014
2014
Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation
K. Metcalfe
,
C. Kim-sing
,
P. Ghadirian
,
P. Sun
,
S. Narod
Clinical genetics
2014
Corpus ID: 19789299
There is a significant variation in the uptake of cancer risk reducing options by women with a BRCA1 or BRCA2 mutation. It is…
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Highly Cited
2011
Highly Cited
2011
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers.
S. Ramus
,
C. Kartsonaki
,
+150 authors
A. Antoniou
Journal of the National Cancer Institute
2011
Corpus ID: 13793217
BACKGROUND Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers…
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Highly Cited
2005
Highly Cited
2005
Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy.
Y. Kirova
,
D. Stoppa-Lyonnet
,
A. Savignoni
,
B. Sigal-Zafrani
,
N. Fabre
,
A. Fourquet
European journal of cancer
2005
Corpus ID: 19490452
2003
2003
BRCA1 and BRCA2 mutation analysis in breast‐ovarian cancer families from northeastern Poland
M. Perkowska
,
I. Brożek
,
+6 authors
J. Limon
Human mutation
2003
Corpus ID: 7001156
Sixty high‐risk breast and/or ovarian cancer families from North‐Eastern Poland were screened for germline mutations in BRCA1…
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1998
1998
High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers
G. Eiriksdottir
,
R. Barkardottir
,
+4 authors
S. Ingvarsson
Oncogene
1998
Corpus ID: 15880359
Breast tumours from BRCA1 and BRCA2 mutation carriers are genetically instable and display specific patterns of chromosomal…
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