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BRCA2 Gene Mutation

Known as: BRCA2 Mutation, Mutation of the BRCA2 Gene 
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small… 
National Institutes of Health

Related topics

Related topics

12 relations
BRCA2 geneColloid Carcinoma of the PancreasHereditary Male Breast CarcinomaHereditary Prostate Carcinoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
Normal breast epithelia from BRCA2 mutation carriers display DNA damage and attenuated checkpoint responses. Women harboring… 
2019
2019
Clinical background and outcomes of risk-reducing salpingo-oophorectomy for hereditary breast and ovarian cancers in Japan
BackgroundThis study aimed to identify the clinical background and treatment outcomes of risk-reducing salpingo-oophorectomy… 
Review
2019
Review
2019
Olaparib maintenance therapy in patients (pts) with a BRCA1 and/or BRCA2 mutation (BRCAm) and newly diagnosed advanced ovarian cancer (OC): SOLO1 China cohort.
5554 Background: SOLO1 (NCT01844986) is a randomized, double-blind, Phase III trial evaluating the efficacy and safety of the… 
2015
2015
Identification of a recurrent BRCA1 exon 21‐22 genomic rearrangement in Malay breast cancer patients
To the Editor: Germline mutations in BRCA1 and BRCA2 are associated with increased risk to breast and ovarian cancer and their… 
2014
2014
Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation
There is a significant variation in the uptake of cancer risk reducing options by women with a BRCA1 or BRCA2 mutation. It is… 
Review
2013
Review
2013
Parental origin of mutation and the risk of breast cancer in a prospective study of women with a BRCA1 or BRCA2 mutation
The objective is to estimate the risk of breast cancer in women who carry a deleterious BRCA1 or BRCA2 mutation, according to… 
2012
2012
A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome.
Review
2010
Review
2010
Effects of ethnicity on genotype-phenotype correlations in individuals with a BRCA1 or BRCA2 mutation.
6060 Background: Genotype-phenotype correlations have yet to be established of know BRCA1/2 mutations. A recent study found that… 
Highly Cited
2010
Highly Cited
2010
Incorporating tumour pathology information into breast cancer risk prediction algorithms
IntroductionMutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian cancer. The risk prediction algorithm… 
1998
1998
High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers
Breast tumours from BRCA1 and BRCA2 mutation carriers are genetically instable and display specific patterns of chromosomal… 
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