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BRCA2 Gene Mutation

Known as: BRCA2 Mutation, Mutation of the BRCA2 Gene 
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small… 
National Institutes of Health

Related topics

Related topics

12 relations
BRCA2 geneColloid Carcinoma of the PancreasHereditary Male Breast CarcinomaHereditary Prostate Carcinoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast…
BACKGROUND In the OlympiAD study, olaparib was shown to improve progression-free survival compared with chemotherapy treatment of… 
Highly Cited
2019
Highly Cited
2019
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast…
Abstract Background In the OlympiAD study, olaparib was shown to improve progression-free survival compared with chemotherapy… 
2017
2017
An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity
Anthracycline-based cardiotoxicity is concerning for women with breast cancer and portends a dose-dependent risk of developing… 
2015
2015
miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers
miRNA deregulation has been found to promote carcinogenesis. Little is known about miRNA deregulation in hereditary breast tumors… 
2014
2014
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The… 
2014
2014
Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation
There is a significant variation in the uptake of cancer risk reducing options by women with a BRCA1 or BRCA2 mutation. It is… 
Highly Cited
2011
Highly Cited
2011
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers.
BACKGROUND Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers… 
Highly Cited
2005
Highly Cited
2005
Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy.
2003
2003
BRCA1 and BRCA2 mutation analysis in breast‐ovarian cancer families from northeastern Poland
Sixty high‐risk breast and/or ovarian cancer families from North‐Eastern Poland were screened for germline mutations in BRCA1… 
1998
1998
High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers
Breast tumours from BRCA1 and BRCA2 mutation carriers are genetically instable and display specific patterns of chromosomal… 
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