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BRCA2 Gene Mutation

Known as: BRCA2 Mutation, Mutation of the BRCA2 Gene 
A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small… Expand
National Institutes of Health

Related topics

Related topics

12 relations
BRCA2 geneColloid Carcinoma of the PancreasHereditary Male Breast CarcinomaHereditary Prostate Carcinoma
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast…
Abstract Background In the OlympiAD study, olaparib was shown to improve progression-free survival compared with chemotherapy… Expand
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2017
2017
An Exploratory Study to Determine Whether BRCA1 and BRCA2 Mutation Carriers Have Higher Risk of Cardiac Toxicity
Anthracycline-based cardiotoxicity is concerning for women with breast cancer and portends a dose-dependent risk of developing… Expand
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2014
2014
Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Background: BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The… Expand
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2014
2014
Health care provider recommendations for reducing cancer risks among women with a BRCA1 or BRCA2 mutation.
There is a significant variation in the uptake of cancer risk reducing options by women with a BRCA1 or BRCA2 mutation. It is… Expand
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2014
2014
Subgroups of familial and aggressive prostate cancer with considerable frequencies of BRCA2 mutations.
BACKGROUND One of the known risk factors for prostate cancer (PrCa) is germline mutations in the BRCA2 gene. Previous searches… Expand
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2011
2011
Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers.
BACKGROUND Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers… Expand
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2009
2009
The Breast and Ovarian Cancer Risks in Korea Due to Inherited Mutations in BRCA1 and BRCA2: A Preliminary Report
trance) of breast and ovarian cancers among female family members with BRCA1 and BRCA2 mutation. Methods: Among the 61 BRCA1… Expand
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Highly Cited
2005
Highly Cited
2005
Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy.
BRCA1 and BRCA2 germline mutations are associated with a strong risk of breast cancer, which may preclude breast-conserving… Expand
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2003
2003
BRCA1 and BRCA2 mutation analysis in breast-ovarian cancer families from northeastern Poland.
Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1… Expand
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1998
1998
High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers
Breast tumours from BRCA1 and BRCA2 mutation carriers are genetically instable and display specific patterns of chromosomal… Expand
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