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Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
Approximately 130,000 cases of col ore eta I cancer (CRC) are diagnosed in the United States each year1, and about 15% of these have a hereditary component2,3. Two well-defined syndromes, familialExpand
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Germline mutations in BAP1 predispose to melanocytic tumors
Common acquired melanocytic nevi are benign neoplasms that are composed of small, uniform melanocytes and are typically present as flat or slightly elevated pigmented lesions on the skin. We describeExpand
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NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017.
The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling for hereditary cancerExpand
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Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.
PURPOSE The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to whatExpand
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Outcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriers.
PURPOSE To prospectively determine the impact of genetic counseling and testing on risk-reduction strategies and cancer incidence in a cohort of individuals at hereditary risk for breast and ovarianExpand
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Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation.
BACKGROUND Risk-reducing salpingo-oophorectomy is often considered by carriers of BRCA mutations who have completed childbearing. However, there are limited data supporting the efficacy of thisExpand
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Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.
The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affectingExpand
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Hereditary cancer predisposition syndromes.
  • J. Garber, K. Offit
  • Medicine
  • Journal of clinical oncology : official journal…
  • 10 January 2005
Cancer genetics is increasingly becoming integrated into the practice of modern medical oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that develop inExpand
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Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
BACKGROUND Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancerExpand
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Genetic/familial high-risk assessment: breast and ovarian.
Names: Lauren Corduck; Ephrat Levy-Lahad, MD; Ranjit Manchanda, MD, MRCOG, PhD; Jill Stopfer, MS, LGC; Elizabeth Etkin-Kramer, MD, FACOG; Patricia Clark, MD; Danielle Shiller, DO; Robin StrausExpand
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