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MUTYH gene

Known as: MUTYH, MutY, E. COLI, HOMOLOG OF, MYH 
This gene plays a role in the repair of oxidative DNA damage.
National Institutes of Health

Related topics

Related topics

5 relations
A/G-Specific Adenine DNA GlycosylaseCell MaintenanceDNA RepairMUTYH-Associate Polyposis

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MUTYH wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Adenine removal activity and bacterial complementation with the human MutY homologue (MUTYH) and Y165C, G382D, P391L and Q324R variants associated with colorectal cancer.
2006
2006
MutY and MutY homologs (MYH) in genome maintenance.
The base excision repair carried out by bacterial MutY DNA glycosylase and eukaryotic MutY homolog (MYH) is responsible for… 
2005
2005
Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer.
Biallelic germline mutations in the base excision repair gene MYH have been shown to predispose to a proportion of multiple… 
Highly Cited
2005
Highly Cited
2005
A kindred with MYH‐associated polyposis and pilomatricomas
MYH‐associated polyposis (MAP) is a recently described autosomal recessive form of familial adenomatous polyposis (FAP… 
Highly Cited
2005
Highly Cited
2005
Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and…
2004
2004
Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients
MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in… 
Highly Cited
2003
Highly Cited
2003
Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome.
May-Hegglin anomaly (MHA), Fechtner syndrome (FTNS), Sebastian syndrome (SBS), and Epstein syndrome (EPS) are a group of rare… 
2003
2003
Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma
The base excision repair gene MYH protects against damage to DNA from reactive oxygen species, which are commonly found in… 
Highly Cited
2002
Highly Cited
2002
Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain‐specific isoforms that localize to neuronal mitochondria
Mitochondrial genomes are exposed to a heavy load of reactive oxygen species (ROS) that damage DNA. Since in neurons… 
2002
2002
Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain
Hypoxia‐associated, acutely reduced blood oxygenation can compromise energy metabolism, alter oxidant/antioxidant balance and… 
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