Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma

  title={Inherited variants in MYH are unlikely to contribute to the risk of lung carcinoma},
  author={Nada Al-Tassan and Tim Eisen and J. Maynard and Helen L. Bridle and Bindiya Shah and Christina Fleischmann and Julian R. Sampson and Jeremy P. Cheadle and Richard S. Houlston},
  journal={Human Genetics},
The base excision repair gene MYH protects against damage to DNA from reactive oxygen species, which are commonly found in cigarette smoke. Inherited mutations in MYH predispose to colorectal adenomas and carcinomas that show a characteristic pattern of somatic G:C→T:A mutations in the APC gene. A similar pattern of somatic mutations in the TP53 gene is reported in smoking-related lung cancers. We therefore tested whether germline changes in MYH may also contribute to the development of lung… CONTINUE READING
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