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A/G-Specific Adenine DNA Glycosylase

Known as: MUTYH, EC 3.2.2.-, hMYH 
A/G-specific adenine DNA glycosylase protein (546 aa, ~60 kDa) is encoded by the MUTYH gene. This nuclear enzyme plays a role in mismatch repair via… 
National Institutes of Health

Related topics

Related topics

9 relations
Base Excision RepairCell MaintenanceCell NucleusColorectal Carcinoma

Papers overview

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2018
2018
Redox Signaling in Eukaryotic DNA Replication and Repair
DNA-mediated charge transport chemistry (DNA CT) offers an intriguing regulatory mechanism in biology, as it is long-range, rapid… 
2016
2016
Structural Studies of the Bacterial MutY Adenine DNA Glycosylase and Its Human Homolog MUTYH
Cellular DNA is under constant threat of reactive oxygen species (ROS) produced by either endogenous or exogenous sources. One of… 
2013
2013
MUTYH the base excision repair gene family member associated with polyposis colorectal cancer
Colorectal cancer is classified in to three forms: sporadic (70-75%), familial (20-25%) and hereditary (5-10%). hereditary… 
2011
2011
Screening for variants in the MUTYH gene in Saudis
MUTYH is a base excision repair glycosylase responsible for correcting the G:A mismatches that arise from replication of a… 
2010
2010
Faithful DNA repair of 7,8-dihydro-8-oxo-guanine lesions by human enzymes
ABSTRACT Reactive oxygen species (ROS) attack DNA and induce, among other lesions, about 1,000 7,8-dihydro-8-oxo-guanine (8… 
2004
2004
MUTYH prevents OGG 1 or APEX 1 from inappropriately processing its substrate or reaction product with its C-terminal domain
MutY homolog (MUTYH) excises adenine opposite 8-oxoguanine(8-oxoG)inDNA,thuspreventingoccurrence of G:C to T:A transversion. In… 
2004
2004
Identification of molecular markers of oxidative stress in human prostate cells
769 Exposure of cultured human prostate cancer cells to androgens has been shown to induce oxidative stress in androgen… 
2003
2003
DNA修復反応の生化学 哺乳類のMutYホモローグ,MUTYHによるAdenineの反対に8-OxoGが結合ミスした修復メカニズム 突然変異と癌発生への関与(Biochemical basis for DNA repair reactions: Repair mechanism of misincorporated adenine opposite 8-oxoG by mammalian…
2002
2002
Potentielle rolle der humanen DNA-reparaturenzyme hMTH1, hOGG1 und hMYHα in der hepatokarzinogenese
ZusammenfassungZur Aufklärung der Rolle dreier DNA-Reparaturenzyme in der Hepatokarzinogenese haben wir die hMTH1, hOGG1 und hMYH… 
2000
2000
Identification of human MutY homolog(hMYH)as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria