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A/G-Specific Adenine DNA Glycosylase

Known as: MUTYH, EC 3.2.2.-, hMYH 
A/G-specific adenine DNA glycosylase protein (546 aa, ~60 kDa) is encoded by the MUTYH gene. This nuclear enzyme plays a role in mismatch repair via… 
National Institutes of Health

Related topics

Related topics

9 relations
Base Excision RepairCell MaintenanceCell NucleusColorectal Carcinoma

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Association of monoallelic MUTYH mutation among Egyptian patients with colorectal cancer
Colorectal cancer (CRC) is a heterogeneous triat that involves both environmental and genetic factors. Genetic mutations of MUTYH… 
2007
2007
Functional characterization of human MutY homolog (hMYH) missense mutation (R231L) that is linked with hMYH-associated polyposis.
2007
2007
Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas.
2007
2007
Acute hypoxia and reoxygenation-induced DNA oxidation in human mononuclear blood cells.
2006
2006
MutY and MutY homologs (MYH) in genome maintenance.
The base excision repair carried out by bacterial MutY DNA glycosylase and eukaryotic MutY homolog (MYH) is responsible for… 
Highly Cited
2005
Highly Cited
2005
Insight into the functional consequences of hMYH variants associated with colorectal cancer: distinct differences in the adenine glycosylase activity and the response to AP endonucleases of Y150C and…
2004
2004
Functional cooperation of Ogg1 and Mutyh in preventing G: C-->T: a transversions in mice.
Oxygen radicals generated through normal cellular metabolism induce a variety of types of oxidative damage into DNA and its… 
2002
2002
Functional Interaction of MutY Homolog with Proliferating Cell Nuclear Antigen in Fission Yeast, Schizosaccharomyces pombe *
The MutY homolog (MYH) is responsible for removing adenines misincorporated on a template DNA strand containing G or 7,8-dihydro… 
Highly Cited
2001
Highly Cited
2001
Differential DNA recognition and glycosylase activity of the native human MutY homolog (hMYH) and recombinant hMYH expressed in bacteria.
Human MutY homolog (hMYH), an adenine DNA glycosylase, can effectively remove misincorporated adenines opposite template G or 8… 
Highly Cited
1998
Highly Cited
1998
Characterization of the Recombinant MutY Homolog, an Adenine DNA Glycosylase, from Yeast Schizosaccharomyces pombe *
The mutY homolog (SpMYH) gene from a cDNA library of Schizosaccharomyces pombeencodes a protein of 461 amino acids that displays… 
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