MLL protein, human

Known as: KMT2A, Histone-Lysine N-Methyltransferase 2A, ALL-1 
Histone-lysine N-methyltransferase MLL (3969 aa, ~432 kDa) is encoded by the human MLL gene. This protein is involved in both histone modification… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
020406019902017

Papers overview

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Highly Cited
2010
Highly Cited
2010
AF4 and ENL family proteins are frequently fused with MLL, and they comprise a higher order complex (designated AEP) containing… (More)
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Highly Cited
2010
Highly Cited
2010
Despite advances in defining the critical molecular determinants for leukemia stem cell (LSC) generation and maintenance, little… (More)
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Highly Cited
2008
Highly Cited
2008
Menin displays the unique ability to either promote oncogenic function in the hematopoietic lineage or suppress tumorigenesis in… (More)
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Highly Cited
2004
Highly Cited
2004
The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric… (More)
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Highly Cited
2003
Highly Cited
2003
The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3,969-amino-acid nuclear protein homologous to Drosophila trithorax… (More)
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Highly Cited
2003
Highly Cited
2003
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal… (More)
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Highly Cited
2003
Highly Cited
2003
We recently found that MLL-rearranged acute lymphoblastic leukemias (MLL) have a unique gene expression profile including high… (More)
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Highly Cited
2002
Highly Cited
2002
MLL (mixed lineage leukemia; also ALL-1 or HRX) is a proto-oncogene that is mutated in a variety of acute leukemias. Its product… (More)
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Highly Cited
2001
Highly Cited
2001
A fragment of the mixed-lineage leukemia (MLL) gene (Mll, HRX, ALL-1) was identified in a yeast genetic screen designed to… (More)
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Highly Cited
1994
Highly Cited
1994
The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations… (More)
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