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MLL protein, human

Known as: KMT2A, Histone-Lysine N-Methyltransferase 2A, ALL-1 
Histone-lysine N-methyltransferase MLL (3969 aa, ~432 kDa) is encoded by the human MLL gene. This protein is involved in both histone modification… 
National Institutes of Health

Related topics

Related topics

15 relations
AT-Hook MotifsBromodomainDNA-Binding ProteinsEnzyme Gene

Broader (2)

Histone-Lysine N-MethyltransferaseMyeloid-Lymphoid Leukemia Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions
Acute myeloid leukemia (AML) is an aggressive hematological malignancy, and the mechanism underlying immune system involvement in… 
2015
2015
Identification of a novel isoform of the leukemia-associated MLLT1 (ENL/LTG19) protein.
2010
2010
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies
2009
2009
Malignant fibrous histiocytoma—pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study
PurposeThe new classification of malignant fibrous histiocytoma leaves only a small group of tumors without further line of… 
2001
2001
The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH
The cell line U937, which has been used extensively for studies of myeloid differentiation, bears the t(10;11)(p13;q14… 
2000
2000
Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins
The human ALL-1 gene is involved in acute leukemia through gene fusions, partial tandem duplications or a specific deletion… 
1996
1996
ALL-1 interacts with unr, a protein containing multiple cold shock domains.
The ALL-1 gene is involved in human acute leukemia through chromosome translocations and fusion to partner genes, or through… 
1995
1995
The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing.
We have previously reported the cloning of several cDNAs corresponding to the MLL gene. The predicted primary amino acid sequence… 
1995
1995
A C4HC3 zinc finger motif.
Metal-binding cysteine and histidine residues are often used to stabilise a protein fold through coordination of zinc ions. These… 
Review
1995
Review
1995
HRX gene rearrangement in secondary acute lymphoblastic leukemia.
The human tri-thorax gene (HRX) also called ALL-1 (Acute Lymphocytic Leukemia-1) as well as MLL (Myeloid-lymphoid or Mixed… 
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