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Histone-Lysine N-Methyltransferase

Known as: Protein Lysine Methyltransferase, Protein Methylase III, Methyltransferase, Histone-Lysine 
An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine… Expand
National Institutes of Health

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Ash1l protein, ratDot1 protein, S cerevisiaeEHMT1 protein, humanEHMT2 protein, human
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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Highly Cited
2015
Highly Cited
2015
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
The gene encoding the lysine-specific histone methyltransferase KMT2D has emerged as one of the most frequently mutated genes in… Expand
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Review
2011
Review
2011
H3K9 methyltransferase G9a and the related molecule GLP.
The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase (HKMT), was reported in 2000. Since… Expand
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Highly Cited
2011
Highly Cited
2011
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple… Expand
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Highly Cited
2009
Highly Cited
2009
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294
Histone lysine methylation is an important epigenetic mark that regulates gene expression and chromatin organization. G9a and G9a… Expand
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Highly Cited
2007
Highly Cited
2007
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
Histone modifications induced by activated signalling cascades are crucial to cell-lineage decisions. Osteoblast and adipocyte… Expand
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Highly Cited
2005
Highly Cited
2005
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to… Expand
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Highly Cited
2005
Highly Cited
2005
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
The growth factor independent 1 (Gfi1) transcriptional regulator oncoprotein plays a crucial role in hematopoietic, inner ear… Expand
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Highly Cited
2004
Highly Cited
2004
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
The Ezh2 protein endows the Polycomb PRC2 and PRC3 complexes with histone lysine methyltransferase (HKMT) activity that is… Expand
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Highly Cited
2004
Highly Cited
2004
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.
Human Enhancer of Zeste homolog (Ezh2) is a histone lysine methyltransferase (HKMT) associated with transcriptional repression… Expand
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Highly Cited
2002
Highly Cited
2002
Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain
The N-terminal tails of core histones are subjected to multiple covalent modifications, including acetylation, methylation, and… Expand
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