Histone-Lysine N-Methyltransferase

Known as: Protein Lysine Methyltransferase, Protein Methylase III, Methyltransferase, Histone-Lysine 
An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
010203019742018

Papers overview

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2012
2012
Although the physiologic significance of lysine methylation of histones is well known, whether lysine methylation plays a role in… (More)
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Highly Cited
2011
Highly Cited
2011
The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple… (More)
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Highly Cited
2009
Highly Cited
2009
The post-translational modifications of histone tails generate a ‘histone code’ that defines local and global chromatin states… (More)
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Highly Cited
2007
Highly Cited
2007
Histone lysine methylation has important roles in the organization of chromatin domains and the regulation of gene expression. To… (More)
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Highly Cited
2005
Highly Cited
2005
Histone lysine methylation has been shown to index silenced chromatin regions at, for example, pericentric heterochromatin or of… (More)
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Highly Cited
2005
Highly Cited
2005
Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to… (More)
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Highly Cited
2004
Highly Cited
2004
Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine… (More)
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Highly Cited
2004
Highly Cited
2004
Human Enhancer of Zeste homolog (Ezh2) is a histone lysine methyltransferase (HKMT) associated with transcriptional repression… (More)
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Highly Cited
2004
Highly Cited
2004
The Ezh2 protein endows the Polycomb PRC2 and PRC3 complexes with histone lysine methyltransferase (HKMT) activity that is… (More)
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2002
2002
Methylation of histone H3 lysine 9 is an important component of the 'histone code' for heterochromatic gene silencing. The SET… (More)
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