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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Structure and ligand of a histone acetyltransferase bromodomain
- C. Dhalluin, Justin E. Carlson, L. Zeng, Cheng He, A. Aggarwal, Ming-Ming Zhou
- 3 June 1999
The solution structure of the bromodomain of the HAT co-activator P/CAF (p300/CBP-associated factor) reveals an unusual left-handed up-and-down four-helix bundle, and it is shown by a combination of structural and site-directed mutagenesis studies that bromidomains can interact specifically with acetylated lysine, making them the first known protein modules to do so.
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
Structure and regulation of MAPK phosphatases.
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of She complexed to a phosphopeptide reveals an alternative means of recognizing tryosine-phosphorylated proteins, suggesting a possible role in membrane localization.
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
- Bo Huang, Xiao-Dong Yang, Ming-Ming Zhou, K. Ozato, Lin-Feng Chen
- Biology, ChemistryMolecular and Cellular Biology
- 22 December 2008
Brd4 is identified as a novel coactivator of NF-κB through specifically binding to acetylated lysine-310 of RelA, and a mechanism by which acetylation of the RelA subunit stimulates the transcriptional activity of NF -κB and the NF-σκB-dependent inflammatory response is revealed.
Bromodomain: an acetyl‐lysine binding domain
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b
The three-dimensional solution structures and biochemical analysis of DPF3b highlight the molecular basis of the integrated tandem PHD finger, which acts as one functional unit in the sequence-specific recognition of lysine-14-acetylated histone H3 (H3K14ac).
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
This work shows that signaling from oncogenic RAS overrides PcG-mediated repression of INK4a by activating the H3K27 demethylase JMJD3 and down-regulating the methyltransferase EZH2, and suggests thatJMJD3 has the capacity to act as a tumor suppressor.