• Publications
  • Influence
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.
The unique selectivity of SNX-482 suggests its usefulness in studying the diversity, function, and pharmacology of class E and/or R-type Ca2+ channels. Expand
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.
A direct comparison between 6-acrylamido-4-anilinoquinazoline and an equally potent but reversible analog shows that the irreversible inhibitor has far superior in vivo antitumor activity in a human epidermoid carcinoma xenograft model with no overt toxicity at therapeutically active doses. Expand
Studying noncovalent protein complexes by electrospray ionization mass spectrometry.
  • J. Loo
  • Chemistry, Medicine
  • Mass spectrometry reviews
  • 1997
Several applications of ESI-MS are discussed, including protein interactions with metal ions and nucleic acids and subunit protein structures (quaternary structure) and mass spectrometry offers advantages in speed and sensitivity. Expand
The cell-shape protein MreC interacts with extracytoplasmic proteins including cell wall assembly complexes in Caulobacter crescentus.
The results suggest that MreC may function in the spatial organization of PBPs as well as other proteins that lie outside the cytoplasmic membrane. Expand
Use of Proteomics to Demonstrate a Hierarchical Oxidative Stress Response to Diesel Exhaust Particle Chemicals in a Macrophage Cell Line*
It is demonstrated that in the dose range 10–100 μg/ml, organic DEP extracts induce a progressive decline in the cellular GSH/GSSG ratio, in parallel with a linear increase in newly expressed proteins on the two-dimensional gel, which suggest that DEP induce a hierarchical oxidative stress response in which some of these proteins may serve as markers for oxidative stress during PM exposures. Expand
Salivary Proteomics for Oral Cancer Biomarker Discovery
Patient-based saliva proteomics is a promising approach to searching for OSCC biomarkers and the discovery of these new targets may lead to a simple clinical tool for the noninvasive diagnosis of oral cancer. Expand
Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane
It is demonstrated that yeast AAC2 physically participates in several protein complexes of distinct size and composition, including the respiratory supercomplex and several smaller AAC2-containing complexes, including other members of the mitochondrial carrier family, are identified here. Expand
Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome.
It is found that WS contains more informative proteins, peptides, and mRNA, as compared with gland-specific saliva, that can be used in generating candidate biomarkers for the detection of primary SS. Expand
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
The findings have unraveled a mechanistic explanation for the angiostatic functions attributed to ADAMTS1 and demonstrated in vivo processing of TSP1 under situations of tissue repair. Expand
Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation
The first system-wide analysis, combining multiple approaches, to correlate the sumoylated proteome (SUMO-ome) in a multicellular organism with the developmental roles of SUMO shows that SUMO coordinates multiple regulatory processes during oogenesis and early embryogenesis. Expand