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Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
It is found that Stat5 phosphorylation in T cells is suppressed in the presence of MSCs and that nitric oxide (NO) is involved in the suppression of Stat5osphorylation and T-cell proliferation, and that NO produced by Mscs is one of the major mediators of T- cell suppression by M SCs. Expand
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes,Expand
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome.
It is determined that the AAV Rep proteins, delivered in cis or trans, are required for integration at AAVS1, and only the large forms of the Rep protein, Rep78 and Rep68, promoted site-specific integration. Expand
Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors
  • Tetsuharu Shinjyo, Ryoko Kuribara, +7 authors T. Inaba
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 1 February 2001
It is concluded that Bim is a pivotal molecule in cytokine regulation of hematopoietic cell survival, since enforced expression of this death activator at levels equivalent to those induced by cytokine withdrawal led to apoptosis even in the presence of IL-3. Expand
Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex
Here, the transduction characteristics of adeno-associated viral vector (AAV) serotypes 1, 2, 5, 8 and 9 in the marmoset cerebral cortex are investigated to investigate the extent of viral spread, cell type tropism, and neuronal transduction efficiency of each serotype. Expand
Neuroprotective Effects of Glial Cell Line-Derived Neurotrophic Factor Mediated by an Adeno-Associated Virus Vector in a Transgenic Animal Model of Amyotrophic Lateral Sclerosis
It is shown here that AAV-GDNF leads to substantial and long-lasting expression of transgenic GDNF in a large number of myofibers with its accumulation at the sites of neuromuscular junctions, indicating that A AV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS. Expand
Gene therapy comes of age
The pioneering work that led the gene therapy field to its current state is reviewed, gene-editing technologies that are expected to play a major role in the field's future are described, and practical challenges in getting these therapies to patients who need them are discussed. Expand
Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase (*)
The association through the C-terminal region of p 130 with Src kinase may facilitate effective hyperphosphorylation of tyrosine residues in the substrate domain of p130, resulting in the binding of SH2-containing molecules to p130. Expand
Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors
It is demonstrated that early hematopoietic progenitors isolated from normal mice rapidly undergo apoptosis in the absence of cytokines, and that Bcr-Abl supports cell survival in part through downregulation of this cell death activator. Expand
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
It is concluded that SLUG is an evolutionarily conserved transcriptional repressor whose activation by E2A-HLF promotes the aberrant survival and eventual malignant transformation of mammalian pro-B cells otherwise slated for apoptotic death. Expand