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Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells.
It is found that Stat5 phosphorylation in T cells is suppressed in the presence of MSCs and that nitric oxide (NO) is involved in the suppression of Stat5osphorylation and T-cell proliferation, and that NO produced by Mscs is one of the major mediators of T- cell suppression by M SCs.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes,…
Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome
It is determined that the AAV Rep proteins, delivered in cis or trans, are required for integration at AAVS1, and only the large forms of the Rep protein, Rep78 and Rep68, promoted site-specific integration.
Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex
Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors
It is concluded that Bim is a pivotal molecule in cytokine regulation of hematopoietic cell survival, since enforced expression of this death activator at levels equivalent to those induced by cytokine withdrawal led to apoptosis even in the presence of IL-3.
Gene therapy comes of age
The pioneering work that led the gene therapy field to its current state is reviewed, gene-editing technologies that are expected to play a major role in the field's future are described, and practical challenges in getting these therapies to patients who need them are discussed.
Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase (*)
- T. Nakamoto, R. Sakai, K. Ozawa, Yoshio Yazaki, H. Hirai
- Biology, ChemistryThe Journal of Biological Chemistry
- 12 April 1996
The association through the C-terminal region of p 130 with Src kinase may facilitate effective hyperphosphorylation of tyrosine residues in the substrate domain of p130, resulting in the binding of SH2-containing molecules to p130.
Neuroprotective Effects of Glial Cell Line-Derived Neurotrophic Factor Mediated by an Adeno-Associated Virus Vector in a Transgenic Animal Model of Amyotrophic Lateral Sclerosis
It is shown here that AAV-GDNF leads to substantial and long-lasting expression of transgenic GDNF in a large number of myofibers with its accumulation at the sites of neuromuscular junctions, indicating that A AV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS.
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.
Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay.
It was found that the G-CSF level rose during the neutropenic phase of cyclic neutropenia and after chemotherapy or bone marrow transplantation (BMT) in three patients with leukemia; also high G-SF levels were positively correlated to blood neutrophil counts in some cases of infectious disorders and lung cancer.