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Myeloid-Lymphoid Leukemia Protein

Known as: Acute Lymphoblastic Leukemia Protein 1, Proto Oncogene Proteins MLL, MLL, Proto-Oncogene Proteins 
Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for… 
National Institutes of Health

Related topics

Related topics

12 relations
In BloodProcess of secretionagonistsantagonists & inhibitors

Narrower (4)

MLL protein, humanMLL-AFX protein, humanMLL-GMPS fusion protein, humanMll2 protein, mouse

Papers overview

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Highly Cited
2015
Highly Cited
2015
Targeting the MLL complex in castration resistant prostate cancer
Resistance to androgen deprivation therapies and increased androgen receptor (AR) activity are major drivers of castration… 
Review
2014
Review
2014
Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.
2014
2014
Dissecting allosteric effects of activator–coactivator complexes using a covalent small molecule ligand
Significance The master coactivator CREB binding protein (CBP)/p300 utilizes several conformationally dynamic protein–protein… 
2014
2014
The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c‐Myb
The KIX domain is a mediator of the interaction between different transcription factors. This complex function is carried out via… 
Review
2013
Review
2013
Mixed lineage leukemia protein in normal and leukemic stem cells
Transcription factors critical for normal hematopoietic stem cell functions are frequently mutated in acute leukemia leading to… 
2010
2010
Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain
2006
2006
HRX-SAFT Equation of State for Fluid Mixtures: Application to Binary Mixtures of Carbon Dioxide, Water, and Methanol
In this work, we extend the pure fluid crossover statistical associating fluid theory (HRX-SAFT) equation of state (EOS) (Kiselev… 
2003
2003
KIX-mediated assembly of the CBP-CREB-HTLV-1 tax coactivator-activator complex.
The HTLV-1 transcriptional activator Tax is required for viral replication and pathogenesis. In concert with human CREB, Tax… 
Highly Cited
2000
Highly Cited
2000
The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation.
Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a role in regulating… 
2000
2000
Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).
The mixed lineage leukemia (MLL) gene located at chromosome band 11q23 is frequently rearranged in patients with therapy-related… 
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