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The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.
The AF10 gene encodes a putative transcription factor containing an N-terminal LAP/PHD zinc finger motif, a functional nuclear localization signal, an AT-hook domain, and a leucine zipper toward theExpand
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Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation.
Leukaemogenesis correlates with alterations in chromatin structure brought about by the gain or loss of interactive domains from regulatory factors that are disrupted by chromosomal translocations.Expand
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Philadelphia positive acute lymphoblastic leukaemia of childhood
On current chemotherapeutic regimens, children with Philadelphia positive acute lymphoblastic leukaemia show a heterogeneous response to treatment. A few respond quickly to treatment and achieveExpand
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The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH
The cell line U937, which has been used extensively for studies of myeloid differentiation, bears the t(10;11)(p13;q14) translocation which results in a fusion between the MLLT10 (myeloid/lymphoid orExpand
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Expression profile of wild‐type ETV6 in childhood acute leukaemia
Summary. Comparative expression analysis of wild‐typeETV6 in the disease state showed an absence of expression in ETV6–CBFA2 acute lymphoblastic leukaemia (ALL) when compared with non‐ETV6–CBFA2 ALLExpand
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Expression pattern and cellular distribution of the murine homologue of AF10.
We have cloned Af10, the murine homologue of the MLL partner gene AF10. The predicted open reading frame of Af10 contains 1069 aa which are 90% identical to those of AF10. Af10 contains an N-terminalExpand
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Cryptic rearrangement involving MLL and AF10 occurring in utero
Chimaeric fusion genes created by nonrandom chromosomal translocations are characteristic of childhood acute lymphoblastic (ALL) and myeloid (AML) leukaemias. Although the mechanisms leading to theseExpand
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Phase 2 study of mitozantrone in combination with chlorambucil and prednisolone for relapsed and refractory non‐Hodgkins lymphoma
Thirty‐six patients with non‐Hodgkin's lymphoma (NHL) (comprising patients with refractory or relapsed disease and eight elderly, unfit patients with de novo disease) were treated with mitozantrone,Expand
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Identical twin marrow transplantation for 5 patients with chronic myeloid leukaemia: Role of DNA finger‐printing to confirm monozygosity in 3 cases
5 patients with chronic myeloid leukaemia (CML) have been treated by BMT from identical twin donors. Syngeneity of the twins was established by conventional methods in the first 2 patients. TheseExpand
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Gene therapy for the haemophilias.
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