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MLH3 protein, human

Known as: mutL homolog 3 (E. coli) protein, human, mutL homolog 3 protein, human, MLH3 
DNA mismatch repair protein Mlh3 (1453 aa, ~164 kDa) is encoded by the human MLH3 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

Related topics

Related topics

9 relations
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein

Broader (1)

MutL Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
SnapShot: DNA Mismatch Repair
Highly Cited
2008
Highly Cited
2008
A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae
Interference-dependent crossing over in yeast and mammalian meioses involves the mismatch repair protein homologs MSH4-MSH5 and… 
Highly Cited
2006
Highly Cited
2006
Common variants in mismatch repair genes and risk of invasive ovarian cancer.
Mismatch repair (MMR) is important for repairing of nucleotide mismatches during DNA replication. Germline mutations in MMR genes… 
Highly Cited
2005
Highly Cited
2005
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
Germ line DNA mismatch repair mutations in MLH1 and MSH2 underlie the vast majority of hereditary non-polyposis colon cancer… 
Highly Cited
2005
Highly Cited
2005
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytes.
In humans, ~50% of conceptuses are chromosomally aneuploid as a consequence of errors in meiosis, and most of these aneuploid… 
Highly Cited
2005
Highly Cited
2005
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and in meiotic recombination. Both… 
Highly Cited
2001
Highly Cited
2001
A role for MLH3 in hereditary nonpolyposis colorectal cancer
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for… 
Highly Cited
2000
Highly Cited
2000
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non… 
Highly Cited
1999
Highly Cited
1999
Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.
The yeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. Using two… 
Highly Cited
1998
Highly Cited
1998
The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations.
The Saccharomyces cerevisiae genome encodes four MutL homologs. Of these, MLH1 and PMS1 are known to act in the MSH2-dependent… 
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