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Multiple loci with different cancer specificities within the 8q24 gene desert.
- M. Ghoussaini, Honglin Song, +30 authors A. Dunning
- Medicine, Biology
- Journal of the National Cancer Institute
- 2 July 2008
It is concluded that there are at least five separate functional variants in this region that are associated with the risk of prostate, colorectal, and ovarian cancer, but not breast cancer. Expand
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.
Among patients with invasive EOC, having a germline mutation in BRCA1 or BRC a2 was associated with improved 5-year overall survival and BRCa2 carriers had the best prognosis. Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks. Expand
Polymorphisms in DNA repair genes and epithelial ovarian cancer risk
- A. Auranen, Honglin Song, +13 authors P. Pharoah
- Biology, Medicine
- International journal of cancer
- 20 November 2005
In this study, some polymorphisms in XRCC2 andXRCC3 genes were associated with EOC risk and further research on the role of these genes on epithelial ovarian cancer is warranted. Expand
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Nine additional candidate loci are reported on and analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development. Expand
Five Glutathione S-Transferase Gene Variants in 23,452 Cases of Lung Cancer and 30,397 Controls: Meta-Analysis of 130 Studies
The risk of lung cancer is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with GSTM3 intron 6 polymorphism and the relevance of the weakly positive overall associations with the GSTM1 null and the GSTT1 null polymorphisms is uncertain. Expand
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer. Expand
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2
A genome-wide association study to identify common ovarian cancer susceptibility alleles was performed, identifying 12 SNPs at 9p22 associated with disease risk and the most significant SNP was genotyped in 2,670 ovarian cancer cases and 4,668 controls. Expand
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
- Honglin Song, E. Dicks, +36 authors P. Pharoah
- Journal of clinical oncology : official journal…
- 10 September 2015
The results confirm that RAD51C and RAD51D are moderate ovarian cancer susceptibility genes and suggest that they confer levels of risk of EOC that may warrant their use alongside BRCA1 and BRCa2 in routine clinical genetic testing. Expand
Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis.
It is suggested that GSTM1 and GSTT1, but not GSTP1 polymorphisms, appear to be associated with a modest increase in the risk of acute lymphoblastic leukaemia, and may play a role in leukemogenesis. Expand