MutL Proteins

Known as: MutL Proteins [Chemical/Ingredient] 
DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak… (More)
National Institutes of Health

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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MLH3 protein, humanPMS1 protein, human

Papers overview

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2011
2011
Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity.
Human and Saccharomyces cerevisiae MutLα, and some bacterial MutL proteins, possess a metal ion-dependent endonuclease activity… (More)
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2009
2009
Adenosine Triphosphate Stimulates Aquifex aeolicus MutL Endonuclease Activity
BACKGROUND Human PMS2 (hPMS2) homologues act to nick 5' and 3' to misincorporated nucleotides during mismatch repair in organisms… (More)
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Highly Cited
2006
Highly Cited
2006
Endonucleolytic function of MutLalpha in human mismatch repair.
Half of hereditary nonpolyposis colon cancer kindreds harbor mutations that inactivate MutLalpha (MLH1*PMS2 heterodimer… (More)
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Highly Cited
2006
Highly Cited
2006
Endonucleolytic Function of MutLα in Human Mismatch Repair
Summary Half of hereditary nonpolyposis colon cancer kindreds harbor mutations that inactivate MutLα (MLH1•PMS2 heterodimer… (More)
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2004
2004
Mismatch repair ensures fidelity of replication and recombination in the radioresistant organism Deinococcus radiodurans
We have characterized the mismatch repair system (MMR) of the highly radiation-resistant type strain of Deinococcus radiodurans… (More)
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Review
2004
Review
2004
GOLDFARB and ALANI 1 Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection , mismatch repair , and non-homologous tail removal
The Saccharomyces cerevisiae mismatch repair (MMR) protein MSH6 and the SGS1 helicase were recently shown to play similarly… (More)
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Highly Cited
2003
Highly Cited
2003
The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.
The Escherichia coli MutS and MutL proteins have been conserved throughout evolution, although their combined functions in… (More)
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2003
2003
Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution.
Type IIA and type IIB topoisomerases each possess the ability to pass one DNA duplex through another in an ATP-dependent manner… (More)
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Review
2003
Review
2003
[Homologs of MutS and MutL during mammalian meiosis].
In eukaryotes, homologs of the Escherichia coli MutS and MutL proteins are crucial for both meiotic recombination and post… (More)
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1995
1995
Single-step purifications of His6-MutH, His6-MutL and His6-MutS repair proteins of escherichia coli K-12.
The MutS, MutH and MutL proteins mediate methyl-directed-mismatch (MDM) repair in Escherichia coli and Salmonella typhimurium… (More)
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