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Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer.
- A. Teschendorff, Usha Menon, +18 authors M. Widschwendter
- Biology, Medicine
- Genome research
- 1 April 2010
Polycomb group proteins (PCGs) are involved in repression of genes that are required for stem cell differentiation. Recently, it was shown that promoters of PCG target genes (PCGTs) are 12-fold more… Expand
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
Summary Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this risk extends to all invasive histological subtypes or borderline tumours is not clear. We… Expand
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
- N. Mavaddat, D. Barrowdale, +130 authors A. Antoniou
- Cancer Epidemiology, Biomarkers & Prevention
- 5 December 2011
Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor… Expand
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.
CONTEXT Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was… Expand
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in… Expand
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were… Expand
Multiple loci with different cancer specificities within the 8q24 gene desert.
- M. Ghoussaini, H. Song, +30 authors A. Dunning
- Medicine, Biology
- Journal of the National Cancer Institute
- 2 July 2008
Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and… Expand
An Epigenetic Signature in Peripheral Blood Predicts Active Ovarian Cancer
Background Recent studies have shown that DNA methylation (DNAm) markers in peripheral blood may hold promise as diagnostic or early detection/risk markers for epithelial cancers. However, to date no… Expand
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.
BACKGROUND Few biomarkers of ovarian cancer prognosis have been established, partly because subtype-specific associations might be obscured in studies combining all histopathological subtypes. We… Expand
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To identify common low-penetrance ovarian cancer susceptibility genes, we conducted a genome-wide association… Expand