MK-421

Summary: The novel prodrug-converting-enzyme (CE) inhibitor perindopril (S9490-3) diacid was found to be as potent as ramipril… Expand

A number of studies have shown short-term hemodynamic and symptomatic improvement in patients with congestive heart failure… Expand

The mechanism of antihypertensive action of converting enzyme (CE) inhibitors was studied by comparing two compounds of different… Expand

Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy… Expand

Dietary sodium restriction reduces vascular smooth muscle, particularly renovascular, responsiveness to infused angiotensin II… Expand

Abstract 1 Two new orally active inhibitors of angiotensin converting enzyme MK421 (enalapril maleate) and its lysine analogue… Expand

1 The disposition of two angiotensin converting-enzyme inhibitor drugs was studied in normal volunteers. One drug was enalapril… Expand

Electrochemically generated hydrogen gas was used to measure local blood flow by Stosseck et al. The data obtained by their… Expand

The effects of the new oral converting enzyme inhibitor "MK-421" on blood pressure, plasma renin activity, plasma angiotensin II… Expand

The parent diacid (N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro of MK-421 inhibited hog plasma angiotensin converting enzyme (ACE… Expand