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MK-421

Known as: MK 421, MK421 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

EnalaprilEnalapril Maleate

Papers overview

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Highly Cited
1986
Highly Cited
1986
Antihypertensive Action of the Converting Enzyme Inhibitor Perindopril (S9490-3) in Spontaneously Hypertensive Rats: Comparison with Enalapril (MK421) and Ramipril (HOE498)
Summary: The novel prodrug-converting-enzyme (CE) inhibitor perindopril (S9490-3) diacid was found to be as potent as ramipril… 
Highly Cited
1985
Highly Cited
1985
Effects of converting enzyme inhibitors: ramipril and enalapril on peptide action and sympathetic neurotransmission in the isolated heart.
The role of converting enzyme (CE) in heart function was studied by assessing the inhibition of CE activity in rat heart tissue… 
Highly Cited
1984
Highly Cited
1984
Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study.
A number of studies have shown short-term hemodynamic and symptomatic improvement in patients with congestive heart failure… 
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Highly Cited
1984
Highly Cited
1984
Is Tissue Converting Enzyme Inhibition a Determinant of the Antihypertensive Efficacy of Converting Enzyme Inhibitors? Studies with the Two Different Compounds, Hoe498 and MK421, in Spontaneously…
The mechanism of antihypertensive action of converting enzyme (CE) inhibitors was studied by comparing two compounds of different… 
Highly Cited
1983
Highly Cited
1983
Endogenous angiotensin II as a determinant of sodium-modulated changes in tissue responsiveness to angiotensin II in normal man.
Dietary sodium restriction reduces vascular smooth muscle, particularly renovascular, responsiveness to infused angiotensin II… 
Highly Cited
1982
Highly Cited
1982
ENALAPRIL (MK-421) AND THE WHITE CELL COUNT AND HAEMATOCRIT
Highly Cited
1982
Highly Cited
1982
Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521.
Abstract 1 Two new orally active inhibitors of angiotensin converting enzyme MK421 (enalapril maleate) and its lysine analogue… 
Highly Cited
1982
Highly Cited
1982
Enalapril maleate and a lysine analogue (MK-521): disposition in man.
1 The disposition of two angiotensin converting-enzyme inhibitor drugs was studied in normal volunteers. One drug was enalapril… 
Highly Cited
1981
Highly Cited
1981
ANTIHYPERTENSIVE EFFECT OF THE NEW ORAL ANGIOTENSIN CONVERTING ENZYME INHIBITOR "MK-421".
The effects of the new oral converting enzyme inhibitor "MK-421" on blood pressure, plasma renin activity, plasma angiotensin II… 
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Highly Cited
1981
Highly Cited
1981
Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.
The parent diacid (N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro of MK-421 inhibited hog plasma angiotensin converting enzyme (ACE… 
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