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MK-421
Known as:
MK 421
, MK421
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Enalapril
Enalapril Maleate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1986
Highly Cited
1986
Antihypertensive Action of the Converting Enzyme Inhibitor Perindopril (S9490-3) in Spontaneously Hypertensive Rats: Comparison with Enalapril (MK421) and Ramipril (HOE498)
T. Unger
,
M. Moursi
,
D. Ganten
,
K. Hermann
,
R. Lang
Journal of Cardiovascular Pharmacology
1986
Corpus ID: 24879388
Summary: The novel prodrug-converting-enzyme (CE) inhibitor perindopril (S9490-3) diacid was found to be as potent as ramipril…
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Highly Cited
1984
Highly Cited
1984
Regression of left ventricular hypertrophy from systemic hypertension by enalapril.
Y. Nakashima
,
F. Fouad
,
R. Tarazi
American Journal of Cardiology
1984
Corpus ID: 32523387
Highly Cited
1984
Highly Cited
1984
Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study.
D. Sharpe
,
J. Murphy
,
R. Coxon
,
S. Hannan
Circulation
1984
Corpus ID: 2565345
A number of studies have shown short-term hemodynamic and symptomatic improvement in patients with congestive heart failure…
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Highly Cited
1984
Highly Cited
1984
Is Tissue Converting Enzyme Inhibition a Determinant of the Antihypertensive Efficacy of Converting Enzyme Inhibitors? Studies with the Two Different Compounds, Hoe498 and MK421, in Spontaneously…
T. Unger
,
D. Ganten
,
R. Lang
,
B. Schölkens
Journal of Cardiovascular Pharmacology
1984
Corpus ID: 24845611
The mechanism of antihypertensive action of converting enzyme (CE) inhibitors was studied by comparing two compounds of different…
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Highly Cited
1984
Highly Cited
1984
Pharmacokinetics of repeated single oral doses of enalapril maleate (MK-421) in normal volunteers.
A. Till
,
H. Gomez
,
+5 authors
A. Lant
Biopharmaceutics & drug disposition
1984
Corpus ID: 7690859
Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy…
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Highly Cited
1982
Highly Cited
1982
ENALAPRIL (MK-421) AND THE WHITE CELL COUNT AND HAEMATOCRIT
G. Griffing
,
J. Melby
The Lancet
1982
Corpus ID: 22163444
Highly Cited
1982
Highly Cited
1982
Pharmacodynamics of converting enzyme inhibition: the cardiovascular, endocrine and autonomic effects of MK421 (enalapril) and MK521.
J. Millar
,
F. Derkx
,
K. McLean
,
J. Reid
British Journal of Clinical Pharmacology
1982
Corpus ID: 37012378
Abstract 1 Two new orally active inhibitors of angiotensin converting enzyme MK421 (enalapril maleate) and its lysine analogue…
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Highly Cited
1982
Highly Cited
1982
Enalapril maleate and a lysine analogue (MK-521): disposition in man.
E. Ulm
,
M. Hichens
,
+6 authors
J. Schelling
British Journal of Clinical Pharmacology
1982
Corpus ID: 21961101
1 The disposition of two angiotensin converting-enzyme inhibitor drugs was studied in normal volunteers. One drug was enalapril…
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Highly Cited
1981
Highly Cited
1981
Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.
D. Gross
,
C. Sweet
,
+7 authors
C. A. Stone
Journal of Pharmacology and Experimental…
1981
Corpus ID: 27040488
The parent diacid (N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro of MK-421 inhibited hog plasma angiotensin converting enzyme (ACE…
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Highly Cited
1981
Highly Cited
1981
Enkephalinase: selective peptide inhibitors.
R. L. Hudgin
,
S. Charleson
,
M. Zimmerman
,
R. Mumford
,
P. L. Wood
Life Science
1981
Corpus ID: 43266905
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