MK-421

Inhibition of angiotensin II generation in the plasma does not fully explain the antihypertensive effects of converting enzyme… (More)

A number of studies have shown short-term hemodynamic and symptomatic improvement in patients with congestive heart failure… (More)

Enalapril is a converting enzyme inhibitor with a prolonged duration of action. We investigated the arterial pressure and… (More)

Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy… (More)

Invasive hemodynamic measurements and determination of baroreflex sensitivity were carried out in 12 mildly sodium-depleted… (More)

Animal studies (particularly in dogs) on enalapril maleate have served to predict the patterns of absorption and elimination… (More)

Enalapril maleate (MK-421), an ethyl ester, is an angiotensin-converting enzyme (ACE) inhibitor from a novel series of… (More)

Nineteen hypertensive patients were treated with increasing doses of the new angiotensin-converting enzyme inhibitor MK 421… (More)

MK 421, at the dose of 25 mg/kg, administered daily by gavage to spontaneously hypertensive rats (SHRs) from their 4th to 15th… (More)

The effects of the new oral converting enzyme inhibitor "MK-421" on blood pressure, plasma renin activity, plasma angiotensin II… (More)