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MK-421

Known as: MK 421, MK421 
 
National Institutes of Health

Papers overview

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Highly Cited
1986
Highly Cited
1986
Summary: The novel prodrug-converting-enzyme (CE) inhibitor perindopril (S9490-3) diacid was found to be as potent as ramipril… Expand
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Highly Cited
1984
Highly Cited
1984
A number of studies have shown short-term hemodynamic and symptomatic improvement in patients with congestive heart failure… Expand
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Highly Cited
1984
Highly Cited
1984
The mechanism of antihypertensive action of converting enzyme (CE) inhibitors was studied by comparing two compounds of different… Expand
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Highly Cited
1984
Highly Cited
1984
Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy… Expand
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Highly Cited
1983
Highly Cited
1983
Dietary sodium restriction reduces vascular smooth muscle, particularly renovascular, responsiveness to infused angiotensin II… Expand
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Highly Cited
1982
Highly Cited
1982
Abstract 1 Two new orally active inhibitors of angiotensin converting enzyme MK421 (enalapril maleate) and its lysine analogue… Expand
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Highly Cited
1982
Highly Cited
1982
1 The disposition of two angiotensin converting-enzyme inhibitor drugs was studied in normal volunteers. One drug was enalapril… Expand
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Highly Cited
1982
Highly Cited
1982
Electrochemically generated hydrogen gas was used to measure local blood flow by Stosseck et al. The data obtained by their… Expand
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Highly Cited
1981
Highly Cited
1981
The effects of the new oral converting enzyme inhibitor "MK-421" on blood pressure, plasma renin activity, plasma angiotensin II… Expand
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Highly Cited
1981
Highly Cited
1981
The parent diacid (N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro of MK-421 inhibited hog plasma angiotensin converting enzyme (ACE… Expand
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