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A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly.
TLDR
Initiation of antihypertensive treatment involving ACE inhibitors in older subjects, particularly men, appears to lead to better outcomes than treatment with diuretic agents, despite similar reductions of blood pressure. Expand
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
TLDR
The use of low‐dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in aificantly lower risk of cardiovascular disease than placebo. Expand
Myocardial infarction increases ACE2 expression in rat and humans.
TLDR
The increase in ACE2 after MI suggests that it plays an important role in the negative modulation of the renin angiotensin system in the generation and degradation of angiotENSin peptides after cardiac injury. Expand
Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
TLDR
The identification of ACE2 in the kidney, its modulation in diabetes, and the recent description that this enzyme plays a biological role in the generation and degradation of various angiotensin peptides provides a rationale to further explore the role of this enzyme in various pathophysiological states including diabetic complications. Expand
Angiotensin receptors: distribution, signalling and function.
TLDR
Recent advances in the understanding of angiotensin II receptors are discussed, in particular, their distribution, signalling and function. Expand
Effect of Aspirin on All‐Cause Mortality in the Healthy Elderly
TLDR
Higher all‐cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer‐related death. Expand
ACE2, a new regulator of the renin–angiotensin system
TLDR
ACE2 might act in a counter-regulatory manner to ACE, modulating the balance between vasoconstrictors and vasodilators within the heart and kidney, and playing a significant role in regulating cardiovascular and renal function. Expand
The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.
TLDR
Clinical studies comparing the effects of antihypertensives on endothelial function suggest differences and Pharmacokinetic properties of various ACE inhibitors indicate that there are differences in their binding characteristics for tissue ACE. Expand
Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats.
TLDR
High dietary salt led to widespread fibrosis and increased TGF-beta1 in the heart and kidney in normotensive and hypertensive rats, and further suggest that excessive salt intake may be an important direct pathogenic factor for cardiovascular disease. Expand
Brachial Blood Pressure But Not Carotid Arterial Waveforms Predict Cardiovascular Events in Elderly Female Hypertensives
TLDR
The present study determined the relative predictive value for cardiovascular disease–free survival of large artery properties as compared with noninvasive brachial blood pressure alone in a population of elderly female hypertensive subjects and found blood pressure measurement alone is superior to measurement of arterial waveforms in predicting outcome in this group. Expand
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