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Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
The use of low‐dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in aificantly lower risk of cardiovascular disease than placebo.
Myocardial infarction increases ACE2 expression in rat and humans.
The increase in ACE2 after MI suggests that it plays an important role in the negative modulation of the renin angiotensin system in the generation and degradation of angiotENSin peptides after cardiac injury.
A comparison of outcomes with angiotensin-converting--enzyme inhibitors and diuretics for hypertension in the elderly.
Initiation of antihypertensive treatment involving ACE inhibitors in older subjects, particularly men, appears to lead to better outcomes than treatment with diuretic agents, despite similar reductions of blood pressure.
Effect of Aspirin on All‐Cause Mortality in the Healthy Elderly
Higher all‐cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer‐related death.
ACE2, a new regulator of the renin–angiotensin system
Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
The identification of ACE2 in the kidney, its modulation in diabetes, and the recent description that this enzyme plays a biological role in the generation and degradation of various angiotensin peptides provides a rationale to further explore the role of this enzyme in various pathophysiological states including diabetic complications.
Angiotensin receptors: distribution, signalling and function.
Recent advances in the understanding of angiotensin II receptors are discussed, in particular, their distribution, signalling and function.
The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data.
Effect of Aspirin on Disability‐free Survival in the Healthy Elderly
Aspirin use in healthy elderly persons did not prolong disability‐free survival over a period of 5 years but led to a higher rate of major hemorrhage than placebo.
Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats.
High dietary salt led to widespread fibrosis and increased TGF-beta1 in the heart and kidney in normotensive and hypertensive rats, and further suggest that excessive salt intake may be an important direct pathogenic factor for cardiovascular disease.