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Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II.
TLDR
Preliminary results suggest that plasma ANG II upregulates renal angiotensinogen gene expression and downregulate renal renin gene expression, a reciprocal feedback regulation that may have important physiological consequences.
Localization of angiotensin converting enzyme in rat heart.
TLDR
Results reveal a markedly nonuniform localization of ACE in the rat heart and suggest possible sites for local angiotensin II generation and bradykinin or other peptide metabolism.
Effect of dietary sodium on angiotensin-converting enzyme (ACE) inhibition and the acute hypotensive effect of enalapril (MK-421) in essential hypertension.
TLDR
Results suggest that regardless of the final mechanism for the antihypertensive action of enalapril it is a consequence of its inhibition of ACE, and a close correlation between plasma drug level, ACE inhibition and the hypotensive effect.
Angiotensin‐Converting Enzyme Inhibitors: Measurement of Relative Inhibitory Potency and Serum Drug Levels by Radioinhibitor Binding Displacement Assay
TLDR
The radioinhibitor binding displacement technique using [125I]MK351A as the ligand for human serum ACE has general application to all competitive ACE inhibitors, allowing comparison of in vitro ACE inhibitor potencies and estimation of serum ACE inhibitor concentrations.
Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat.
TLDR
Analysis of rats with the two-kidney one-clip model of renovascular hypertension found marked interstitial fibrosis and tubular atrophy of the clipped kidneys from the enalapril treated group in contrast to minor changes in the minoxidil treated and untreated groups.
Glomerular Filtration Rate in Streptozocin-Induced Diabetic Rats: Role of Exchangeable Sodium, Vasoactive Hormones, and Insulin Therapy
The interrelationships of sodium and volume status, atrial natriuretic peptide (ANP), plasma renin activity (PRA), insulinlike growth factor I (IGF-I), and kidney weight and their influence on
BLOCKADE OF ANGIOTENSIN CONVERTING ENZYME IN CIRCUMVENTRICULAR ORGANS OF THE BRAIN AFTER ORAL LISINOPRIL ADMINISTRATION DEMONSTRATED BY QUANTITATIVE IN VITRO AUTORADIOGRAPHY
1. To elucidate the central effect of lisinopril, a new angiotensin converting enzyme (ACE) inhibitor, ACE localization and levels were followed in the brain of Sprague‐Dawley rats by quantitative in
Angiotensin converting enzyme (ACE), characterization by 125I-MK351A binding studies of plasma and tissue ACE during variation of salt status in the rat.
TLDR
Across the range of sodium states studied there were no consistent changes in plasma, lung, aorta, brain, epididymis or kidney MK351A binding sites/mg protein, or equilibrium dissociation constant, which was uniform within each tissue, but varied between organs.
Inhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography.
TLDR
It is established that lisinopril has differential effects on inhibiting ACE in different tissues and suggested that the prolonged tissue ACE inhibition after a single oral dose of lisinipril may reflect targets involved in the hypotensive action of ACE inhibitors.
Inhibition of angiotensin converting enzyme (ACE) in plasma and tissues: studies ex vivo after administration of ACE inhibitors.
TLDR
Preliminary results suggest that after chronic administration there is also a variable pattern of induction and inhibition of ACE in different tissues, and it may be possible to determine the role of local renin-angiotensin systems in regional haemodynamics and in the hypotensive action of ACE inhibitors.
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