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Trichuris suis therapy in Crohn’s disease
Background: Crohn’s disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths… Expand
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
Tuft cells help contain parasites Trillions of microbes inhabit our guts, including worms and other parasites. Epithelial cells that line the gut orchestrate parasite-targeted immune responses.… Expand
Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial.
BACKGROUND & AIMS Ulcerative colitis is most common in Western industrialized countries. Inflammatory bowel disease is uncommon in developing countries where helminths are frequent. People with… Expand
Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease
- R. Summers, D. Elliott, K. Qadir, J. Urban, R. Thompson, J. Weinstock
- American Journal of Gastroenterology
- 1 September 2003
OBJECTIVES:Inflammatory bowel disease (IBD), especially Crohn's disease (CD), probably results from failure to downregulate a chronic Th1 intestinal inflammatory process. Induction of a Th2 immune… Expand
Rapid development of colitis in NSAID-treated IL-10-deficient mice.
BACKGROUND & AIMS Interleukin (IL)-10 is an anti-inflammatory and immune regulatory cytokine. IL-10-deficient mice (IL-10(-/-)) develop chronic inflammatory bowel disease (IBD), indicating that… Expand
Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization.
Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS) characterized by chronic inflammatory demyelination of the central nervous system (CNS). The pathology… Expand
Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.
Asthma has been increasing in industrialized countries. Evidence suggests that asthma is caused by a Th2 immune response to inhaled environmental Ags and that childhood infections protect against… Expand
Exposure to schistosome eggs protects mice from TNBS-induced colitis.
- D. Elliott, J. Li, +4 authors J. Weinstock
- Biology, Medicine
- American journal of physiology. Gastrointestinal…
- 1 March 2003
Crohn's disease results from dysregulated T helper (Th)1-type mucosal inflammation. Crohn's disease is rare in tropical countries but prevalent in developed countries with temperate climates, in… Expand
Mechanisms of Disease: the hygiene hypothesis revisited
- Francisco Guarner, R. Bourdet-Sicard, +6 authors G. Rook
- Nature Clinical Practice Gastroenterology…
- 1 May 2006
In industrialized countries the incidence of diseases caused by immune dysregulation has risen. Epidemiologic studies initially suggested this was connected to a reduction in the incidence of… Expand
Alteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrus
- S. Walk, A. Blum, S. A. Ewing, J. Weinstock, V. Young
- Biology, Medicine
- Inflammatory bowel diseases
- 1 November 2010
Background: In a murine model of inflammatory bowel disease (IBD), treatment of colitis in IL‐10 gene‐deficient mice with the parasitic helminth Heligmosomoides polygyrus ameliorates colonic… Expand