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MBD4 gene

Known as: MBD4, Methyl-CpG Binding Domain Protein 4 Gene, METHYL-CpG-BINDING DOMAIN PROTEIN 4 
This gene is involved in DNA mismatch repair.
National Institutes of Health

Related topics

Related topics

9 relations
DNA RepairHydrolysisMBD4 protein, humanMBD5 gene

Narrower (1)

MED1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
MBD4 Interacts With and Recruits USP7 to Heterochromatic Foci
MBD4 is the only methyl‐CpG binding protein that possesses a C‐terminal glycosylase domain. It has been associated with a number… 
Highly Cited
2013
Highly Cited
2013
Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers.
2008
2008
Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype.
2008
2008
Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells.
2008
2008
MBD4-Mediated Glycosylase Activity on a Chromatin Template Is Enhanced by Acetylation
ABSTRACT The ability of the MBD4 glycosylase to excise a mismatched base from DNA has been assessed in vitro using DNA substrates… 
Highly Cited
2007
Highly Cited
2007
Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients
Global DNA hypomethylation in CD4+ T cells has been detected in systemic lupus erythematosus (SLE), and it seems to be linked to… 
2006
2006
Distinct Roles of the Steroid Receptor Coactivator 1 and of MED1 in Retinoid-induced Transcription and Cellular Differentiation*
Retinoic acid receptors (RARs) are the molecular relays of retinoid action on transcription, cellular differentiation and… 
2004
2004
MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR
Mbd4 (methyl-binding domain 4) has been shown to be mutated in a high percentage of mismatch repair (MMR)-deficient colorectal… 
2003
2003
MBD4 mutations are rare in gastric carcinomas with microsatellite instability.
2003
2003
Microsatellite instability and MBD4 mutation in unselected colorectal cancer.
BACKGROUND We investigated the prognostic significance of microsatellite instability (MSI) and the association with… 
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