FAQ

MBD4 gene

Known as: MBD4, Methyl-CpG Binding Domain Protein 4 Gene, METHYL-CpG-BINDING DOMAIN PROTEIN 4 
This gene is involved in DNA mismatch repair.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
024619982018

Related topics

Related topics

9 relations
DNA RepairHydrolysisMBD4 protein, humanMBD5 gene
(More)

Narrower (1)

MED1 wt Allele

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
MBD4 gene
Hydrolysis
DNA Repair
dna binding
Mismatch Repair
MBD4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos.
Loss of the of the maintenance methyltransferase xDNMT1 during Xenopus development results in premature transcription and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2007
2007
Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients.
Global DNA hypomethylation in CD4+ T cells has been detected in systemic lupus erythematosus (SLE), and it seems to be linked to… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
2006
2006
Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH.
BACKGROUND & AIMS Hyperplastic polyposis syndrome (HPS) is defined phenotypically with multiple, large and/or proximal… (More)
Is this relevant?
2006
2006
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor.
The Mediator subunits MED14 and MED1 have been implicated in transcriptional regulation by the glucocorticoid receptor (GR) by… (More)
Is this relevant?
2005
2005
The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes.
Epigenetic silencing through methyl-CpG (mCpG) is implicated in many biological patterns such as genome imprinting, X chromosome… (More)
Is this relevant?
2003
2003
MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
MBD4 was originally identified through its methyl binding domain, but has more recently been characterized as a thymine DNA… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.
The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
1999
1999
Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency
Defects of mismatch repair are thought to be responsible for carcinogenesis in hereditary non-polyposis colorectal cancer and… (More)
  • figure 1
Is this relevant?
1999
1999
Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes
DNA methylation is essential for murine development and is implicated in the control of gene expression. MeCP2, MBD1, MBD2, MBD3… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse
 
  • figure 2
  • figure 1
  • figure 2
  • figure 1
Is this relevant?