MBD4 gene

Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using… Expand

Global DNA hypomethylation in CD4+ T cells has been detected in systemic lupus erythematosus (SLE), and it seems to be linked to… Expand

BACKGROUND & AIMS Hyperplastic polyposis syndrome (HPS) is defined phenotypically with multiple, large and/or proximal… Expand

BackgroundThe hCMV promoter is very commonly used for high level expression of transgenes in mammalian cells, but its utility is… Expand

ABSTRACT Epigenetic silencing through methyl-CpG (mCpG) is implicated in many biological patterns such as genome imprinting, X… Expand

The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a… Expand

A 1468 bp cDNA coding for the chicken homolog of the human MBD4 G/T mismatch DNA glycosylase was isolated and sequenced. The… Expand

In addition to its well-documented effects on gene silencing, cytosine methylation is a prominent cause of mutations. In humans… Expand

Defects of mismatch repair are thought to be responsible for carcinogenesis in hereditary non-polyposis colorectal cancer and… Expand

Abstract. DNA methylation is essential for murine development and is implicated in the control of gene expression. MeCP2, MBD1… Expand