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MBD4 gene

Known as: MBD4, Methyl-CpG Binding Domain Protein 4 Gene, METHYL-CpG-BINDING DOMAIN PROTEIN 4 
This gene is involved in DNA mismatch repair.
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using… Expand
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Highly Cited
2007
Highly Cited
2007
Global DNA hypomethylation in CD4+ T cells has been detected in systemic lupus erythematosus (SLE), and it seems to be linked to… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Hyperplastic polyposis syndrome (HPS) is defined phenotypically with multiple, large and/or proximal… Expand
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Highly Cited
2005
Highly Cited
2005
BackgroundThe hCMV promoter is very commonly used for high level expression of transgenes in mammalian cells, but its utility is… Expand
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Highly Cited
2005
Highly Cited
2005
ABSTRACT Epigenetic silencing through methyl-CpG (mCpG) is implicated in many biological patterns such as genome imprinting, X… Expand
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Highly Cited
2002
Highly Cited
2002
The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a… Expand
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Highly Cited
2000
Highly Cited
2000
A 1468 bp cDNA coding for the chicken homolog of the human MBD4 G/T mismatch DNA glycosylase was isolated and sequenced. The… Expand
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Highly Cited
1999
Highly Cited
1999
In addition to its well-documented effects on gene silencing, cytosine methylation is a prominent cause of mutations. In humans… Expand
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Highly Cited
1999
Highly Cited
1999
Defects of mismatch repair are thought to be responsible for carcinogenesis in hereditary non-polyposis colorectal cancer and… Expand
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Highly Cited
1999
Highly Cited
1999
Abstract. DNA methylation is essential for murine development and is implicated in the control of gene expression. MeCP2, MBD1… Expand
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