MBD4 protein, human

Known as: MBD4, G/U Mismatch Glycosylase, methyl-CpG binding domain protein 4, human 
Methyl-CpG-binding domain protein 4 (580 aa, ~66 kDa) is encoded by the human MBD4 gene. This protein is involved in the DNA mismatch-specific… (More)

Topic mentions per year

Topic mentions per year

1998-2018
051019982018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in gene expression control and disease pathogenesis… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
BACKGROUND The combination of complete diaphragm inactivity and mechanical ventilation (for more than 18 hours) elicits disuse… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The mammalian protein MBD4 contains a methyl-CpG binding domain and can enzymatically remove thymine (T) or uracil (U) from a… (More)
  • table 1
  • figure 1
  • figure 2
Is this relevant?
2000
2000
The human protein MED1 (also known as MBD4) was previously isolated in a two-hybrid screening using the mismatch repair protein… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
A 1468 bp cDNA coding for the chicken homolog of the human MBD4 G/T mismatch DNA glycosylase was isolated and sequenced. The… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
In addition to its well-documented effects on gene silencing, cytosine methylation is a prominent cause of mutations. In humans… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
266 nature genetics • volume 23 • november 1999 Most tumours arising in individuals affected with hereditary non-polyposis… (More)
  • table 1
  • figure 1
Is this relevant?
1999
1999
DNA methylation is essential for murine development and is implicated in the control of gene expression. MeCP2, MBD1, MBD2, MBD3… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Methylation at the DNA sequence 5'-CpG is required for mouse development. MeCP2 and MBD1 (formerly PCM1) are two known proteins… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • table 1
Is this relevant?