• Publications
  • Influence
DNA methylation patterns and epigenetic memory.
  • A. Bird
  • Biology
    Genes & development
  • 2002
The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
The overlapping delay before symptom onset in humans and mice raises the possibility that stability of brain function, not brain development per se, is compromised by the absence of MeCP2, and generates mice lacking Mecp2 using Cre-loxP technology.
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2, an abundant nuclear protein that is essential for mouse embryogenesis.
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
The data demonstrate that MBD2 and MBD4 bind specifically to methyl-CpG in vitro and in vivo and are therefore likely to be mediators of the biological consequences of the methylation signal.
CpG islands and the regulation of transcription.
Vertebrate CpG islands are generically equipped to influence local chromatin structure and simplify regulation of gene activity.
Genomic DNA methylation: the mark and its mediators.
DNA methylation landscapes: provocative insights from epigenomics
The conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged and not only is promoter methylation often highly dynamic during development, but many organisms also seem to targetDNA methylation specifically to the bodies of active genes.
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
A novel polypeptide highly related to the metastasis-associated protein 1, MTA2, and the methyl-CpG-binding domain-containing protein, MBD3, were found to be subunits of the NuRD complex, which may provide a means of gene silencing by DNA methylation.
CpG-rich islands and the function of DNA methylation
It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated. Highly tissue-specific genes, though, usually lack islands. The