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DNA methylation patterns and epigenetic memory.
- A. Bird
- Biology, Medicine
- Genes & development
- 2002
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding… Expand
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
- R. Jaenisch, A. Bird
- Biology, Medicine
- Nature Genetics
- 1 March 2003
Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in gene… Expand
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
- J. Guy, B. Hendrich, M. Holmes, J. Martin, A. Bird
- Biology, Medicine
- Nature Genetics
- 2001
Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs once in 10,000–15,000 births. Affected females develop normally for 6–18 months, but then lose voluntary… Expand
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term silencing of certain genes during… Expand
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
- B. Hendrich, A. Bird
- Biology, Medicine
- Molecular and Cellular Biology
- 1 November 1998
ABSTRACT Methylation at the DNA sequence 5′-CpG is required for mouse development. MeCP2 and MBD1 (formerly PCM1) are two known proteins that bind specifically to methylated DNA via a related amino… Expand
CpG islands and the regulation of transcription.
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most,… Expand
Genomic DNA methylation: the mark and its mediators.
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known,… Expand
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
- Y. Zhang, H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, D. Reinberg
- Biology, Medicine
- Genes & development
- 1 August 1999
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex containing nucleosome remodeling… Expand
DNA methylation landscapes: provocative insights from epigenomics
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome… Expand
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
- J. Lewis, R. Meehan, W. Henzel, I. Maurer-Fogy, A. Bird
- Biology, Medicine
- Cell
- 12 June 1992
Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between the… Expand
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