• Publications
  • Influence
DNA methylation patterns and epigenetic memory.
  • A. Bird
  • Biology, Medicine
  • Genes & development
  • 2002
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-bindingExpand
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  • 245
  • PDF
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in geneExpand
  • 5,193
  • 178
  • PDF
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs once in 10,000–15,000 births. Affected females develop normally for 6–18 months, but then lose voluntaryExpand
  • 1,405
  • 168
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term silencing of certain genes duringExpand
  • 3,247
  • 158
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
ABSTRACT Methylation at the DNA sequence 5′-CpG is required for mouse development. MeCP2 and MBD1 (formerly PCM1) are two known proteins that bind specifically to methylated DNA via a related aminoExpand
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  • 123
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CpG islands and the regulation of transcription.
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most,Expand
  • 2,214
  • 109
  • PDF
Genomic DNA methylation: the mark and its mediators.
  • R. Klose, A. Bird
  • Biology, Medicine
  • Trends in biochemical sciences
  • 1 February 2006
Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known,Expand
  • 2,255
  • 92
  • PDF
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex containing nucleosome remodelingExpand
  • 1,141
  • 85
DNA methylation landscapes: provocative insights from epigenomics
The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genomeExpand
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between theExpand
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