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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between theExpand
Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2.
MeCP2 is a chromosomal protein which binds to DNA that is methylated at CpG. In situ immunofluorescence in mouse cells has shown that the protein is most concentrated in pericentromericExpand
Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.
Methylated DNA in vertebrates is associated with transcriptional repression and inactive chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically to DNA containingExpand
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
The effects of DNA methylation on transcription and chromatin structure require that nuclear factors be able to distinguish methylated and nonmethylated DNA. We describe a methyl-CpG binding proteinExpand
HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain
We have isolated the complete coding sequences for two Xenopus laevis isoforms of heterochromatin protein 1, corresponding to HP1α and HP1γ. The sequence of xHP1α shows considerable divergence fromExpand
A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins
Methylation of cytosines within the sequence CpG is essential for mouse development1 and has been linked to transcriptional suppression in vertebrate systems2. Methyl-CpG binding proteins (MeCPs) 1Expand
Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells hasExpand
Effect of Limited DNA Methylation Reprogramming in the Normal Sheep Embryo on Somatic Cell Nuclear Transfer1
Abstract Active demethylation of cytosine residues in the sperm genome before forming a functional zygotic nucleus is thought to be an important function of the oocyte cytoplasm for subsequentExpand
Non-conservation of mammalian preimplantation methylation dynamics
In mammals, active demethylation of sperm pronuclear DNA shortly after fertilisation is thought to be important for reprogramming subsequent embryonic development [1–3]. A further passive loss ofExpand
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% ofExpand