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MAP3K8 protein, human

Known as: oncoprotein kinase Tpl2, human, Proto-Oncogene c-Cot, MAP3K8 
Mitogen-activated protein kinase kinase kinase 8 (467 aa, ~58 kDa) is encoded by the human MAP3K8 gene. This protein plays a role in T cell… 
National Institutes of Health

Related topics

Related topics

23 relations
Cell Cycle ControlEnzyme GeneMAP3K1 protein, humanMAP3K13 protein, human

Broader (3)

MAP Kinase Kinase KinaseProto-Oncogene Proteinsstress-activated protein kinase 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Coordinate Regulation of TPL-2 and NF-κB Signaling in Macrophages by NF-κB1 p105
ABSTRACT The role of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in innate immune signaling was investigated using… 
Highly Cited
2007
Highly Cited
2007
Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages
ABSTRACT Tumor progression locus 2 (TPL-2) kinase is essential for Toll-like receptor 4 activation of the mitogen-activated… 
Highly Cited
2006
Highly Cited
2006
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
The TPL-2 MEK kinase is essential for activation of the Erk MAP kinase pathway during innate immune responses. TPL-2 is found in… 
Highly Cited
2004
Highly Cited
2004
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… 
Highly Cited
2004
Highly Cited
2004
ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability
ABSTRACT NF-κB1 p105 forms a high-affinity, stoichiometric interaction with TPL-2, a MEK kinase essential for TLR4 activation of… 
2003
2003
NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.
Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus. This mutation also… 
Highly Cited
2002
Highly Cited
2002
The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-κB Signaling Downstream of TRAF2
ABSTRACT The Epstein-Barr virus-encoded latent infection membrane protein 1 (LMP1) is a pleiotropic protein, the activities of… 
Highly Cited
1998
Highly Cited
1998
Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB
The Tpl-2 kinase activates the nuclear factor of activated T cells (NFAT) and induces IL-2 expression in T-cell lines. Here we… 
Highly Cited
1997
Highly Cited
1997
Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Provirus insertion in the last intron of the Tpl-2 gene in retrovirus-induced rat T-cell lymphomas results in the enhanced… 
Highly Cited
1996
Highly Cited
1996
Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase.
The Tpl‐2 protein serine/threonine kinase was originally identified, in a C‐terminally deleted form, as the product of an… 
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