MAP3K8 protein, human

Known as: oncoprotein kinase Tpl2, human, Proto-Oncogene c-Cot, MAP3K8 
Mitogen-activated protein kinase kinase kinase 8 (467 aa, ~58 kDa) is encoded by the human MAP3K8 gene. This protein plays a role in T cell… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
051019842018

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase… (More)
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Highly Cited
2009
Highly Cited
2009
Stimulation of Toll-like receptors (TLRs) on macrophages and dendritic cells (DCs) by pathogen-derived products induces the… (More)
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2009
2009
Human bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into numerous cell lineages, making them ideal for… (More)
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Highly Cited
2007
Highly Cited
2007
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptors 4/5 and selectively induces caspase… (More)
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2004
2004
NF-kappa B1 p105 forms a high-affinity, stoichiometric interaction with TPL-2, a MEK kinase essential for TLR4 activation of the… (More)
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2003
2003
Activation of the oncogenic potential of the MEK kinase TPL-2 (Cot) requires deletion of its C terminus. This mutation also… (More)
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Highly Cited
1999
Highly Cited
1999
The proto-oncogene Cot/Tpl-2 encodes a MAP3K-related serine-threonine kinase. Expression of wild type Cot activates the IkappaB… (More)
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1999
1999
The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides… (More)
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1997
1997
Provirus insertion in the last intron of the Tpl-2 gene in retrovirus-induced rat T-cell lymphomas results in the enhanced… (More)
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Highly Cited
1996
Highly Cited
1996
The Tpl-2 protein serine/threonine kinase was originally identified, in a C-terminally deleted form, as the product of an… (More)
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