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MAP3K8 protein, human

Known as: oncoprotein kinase Tpl2, human, Proto-Oncogene c-Cot, MAP3K8 
Mitogen-activated protein kinase kinase kinase 8 (467 aa, ~58 kDa) is encoded by the human MAP3K8 gene. This protein plays a role in T cell… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by… Expand
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Highly Cited
2014
Highly Cited
2014
Background: Low intensity pulsed ultrasound (LIPUS) is a mechanical stimulus clinically used to promote bone fracture healing… Expand
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Highly Cited
2012
Highly Cited
2012
ABSTRACT The role of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in innate immune signaling was investigated using… Expand
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Highly Cited
2010
Highly Cited
2010
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas. Pre… Expand
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Highly Cited
2004
Highly Cited
2004
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The MEK kinase TPL-2 (also known as Cot) is required for lipopolysaccharide (LPS) activation of the extracellular signal… Expand
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Highly Cited
1999
Highly Cited
1999
The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides… Expand
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Highly Cited
1997
Highly Cited
1997
Provirus insertion in the last intron of the Tpl-2 gene in retrovirus-induced rat T-cell lymphomas results in the enhanced… Expand
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Highly Cited
1996
Highly Cited
1996
The region upstream of the multiple antibiotic resistance efflux operon mexA-mexB-oprM in Pseudomonas aeruginosa was sequenced… Expand
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Highly Cited
1996
Highly Cited
1996
The Tpl-2 protein serine/threonine kinase was originally identified, in a C-terminally deleted form, as the product of an… Expand
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