Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes

@article{Akey2004PopulationHA,
  title={Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes},
  author={Joshua M. Akey and Michael Eberle and Mark J. Rieder and Christopher S Carlson and Mark D. Shriver and Deborah A. Nickerson and Leonid Kruglyak},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={1805 - 1814}
}
Identifying regions of the human genome that have been targets of natural selection will provide important insights into human evolutionary history and may facilitate the identification of complex disease genes. Although the signature that natural selection imparts on DNA sequence variation is difficult to disentangle from the effects of neutral processes such as population demographic history, selective and demographic forces can be distinguished by analyzing multiple loci dispersed throughout… CONTINUE READING
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