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MADD gene

Known as: DENN, MAP-Kinase Activating Death Domain Gene, INSULINOMA-GLUCAGONOMA PROTEIN 20 
This proto-oncogene is involved in the regulation of apoptosis and propagates cell death via signal transduction.
National Institutes of Health

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Related topics

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ApoptosisCell Death Signaling ProcessMADD proteinPositive Regulation of Apoptosis

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MADD wt Allele

Papers overview

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2015
2015
Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein
The folliculin/Fnip complex has been demonstrated to play a crucial role in the mechanisms underlying Birt–Hogg–Dubé (BHD… 
2014
2014
Function of the Mon1-Ccz1 complex on endosomes
Rabs exist in two forms: the inactive GDP- and the active GTP-bound form. GEF proteins mediate the exchange of GDP for GTP and… 
2013
2013
Identification of a novel SBF2 missense mutation associated with a rare case of thrombocytopenia using whole-exome sequencing
We describe in this report a case of a 6-years-old female who presented at the age of 1 month with a mucocutaneous bleeding and… 
2010
2010
Akt-phosphorylated Mitogen-activated Kinase-activating Death Domain Protein (MADD) Inhibits TRAIL-induced Apoptosis by Blocking Fas-associated Death Domain (FADD) Association with Death Receptor 4*
MADD plays an essential role in cancer cell survival. Abrogation of endogenous MADD expression results in significant spontaneous… 
2009
2009
Disruption of ST5 is associated with mental retardation and multiple congenital anomalies
Background The authors observed a patient with a cryptic subtelomeric de novo balanced translocation 46,XY.ish t(11;20)(p15.4;q13… 
2007
2007
MADD/DENN Splice Variant of the IG20 Gene Is a Negative Regulator of Caspase-8 Activation
The MADD variant of the IG20 gene is necessary and sufficient for cancer cell survival. Abrogation of MADD, but not the other… 
2004
2004
IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC
Recently, we identified Insulinoma–Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor… 
2004
2004
Die Feinstruktur der Kieselsäure und ihre physiologische Bedeutung in Diatomeenschalen
In den v e r g a n g e n e n J a h r e n wurden sehr viele Schalen einzelner Dia tomeenze l len von fiber 500 Ar ten auf ihre m o… 
2003
2003
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.
The IG20 gene encodes at least four splice variants, including DENN-SV and IG20. DENN-SV is constitutively expressed at higher… 
1996
1996
DENN, a novel human gene differentially expressed in normal and neoplastic cells.
A novel 5843 bp human cDNA sequence was isolated from fetal liver cDNA using the RACE procedure. Within this cDNA was… 
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