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MADD protein

Known as: Insulinoma-Glucagonoma Protein 20, MAP Kinase-Activating Death Domain Protein, MAP-Kinase Activating Death Domain-Containing Protein 
Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid… 
National Institutes of Health

Related topics

Related topics

17 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneBrainCell Death Signaling Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with…
BACKGROUND The IG20/MADD gene is overexpressed in thyroid cancer tissues and cell lines, and can contribute to tumor necrosis… 
2010
2010
Akt-phosphorylated Mitogen-activated Kinase-activating Death Domain Protein (MADD) Inhibits TRAIL-induced Apoptosis by Blocking Fas-associated Death Domain (FADD) Association with Death Receptor 4*
MADD plays an essential role in cancer cell survival. Abrogation of endogenous MADD expression results in significant spontaneous… 
2010
2010
Who is MADD? Mixed anxiety depressive disorder in the general population.
2007
2007
MADD/DENN Splice Variant of the IG20 Gene Is a Negative Regulator of Caspase-8 Activation
The MADD variant of the IG20 gene is necessary and sufficient for cancer cell survival. Abrogation of MADD, but not the other… 
2004
2004
IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC
Recently, we identified Insulinoma–Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor… 
2003
2003
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.
The IG20 gene encodes at least four splice variants, including DENN-SV and IG20. DENN-SV is constitutively expressed at higher… 
2001
2001
Evaluation of the effects of North Carolina's 0.08% BAC law.
Review
1994
Review
1994
In the Pink: MADD and Public Health Policy in the 1990s
We examine a turnaround by MADD in 1992 on a major public health policy issue: the question of possible limits on and required… 
1991
1991
Design of 3-dimensional complex airplane configurations with specified pressure distribution via optimization
A subcritical panel method applied to flow analysis and aerodynamic design of complex aircraft configurations is presented. The… 
1986
1986
System analysis of Phycomyces light-growth response: Single mutants
The white-noise method of system identification has been applied to the transient light-growth response of a set of seven mutants… 
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