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MADD protein

Known as: Insulinoma-Glucagonoma Protein 20, MAP Kinase-Activating Death Domain Protein, MAP-Kinase Activating Death Domain-Containing Protein 
Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid… 
National Institutes of Health

Related topics

Related topics

17 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneBrainCell Death Signaling Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Downregulation of miR-522 suppresses proliferation and metastasis of non-small cell lung cancer cells by directly targeting DENN/MADD domain containing 2D
Non-small cell lung cancer (NSCLC), one of the most common causes of cancer-related death, is a worldwide public health problem… 
2011
2011
Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
Introduction Recent meta-analyses of genome-wide association studies revealed new genetic loci associated with fasting glycemia… 
Review
2010
Review
2010
State of the art in muscle lipid diseases
Fatty acid oxidation in mitochondrial matrix is a major source of energy in muscle, especially when physiological energy demand… 
2010
2010
Akt-phosphorylated Mitogen-activated Kinase-activating Death Domain Protein (MADD) Inhibits TRAIL-induced Apoptosis by Blocking Fas-associated Death Domain (FADD) Association with Death Receptor 4*
MADD plays an essential role in cancer cell survival. Abrogation of endogenous MADD expression results in significant spontaneous… 
2006
2006
MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival
The IG20 gene is overexpressed in human tumors and cancer cell lines, and encodes at least four splice variants (SVs) namely… 
Highly Cited
2004
Highly Cited
2004
Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons
Tumor necrosis factor (TNF) α and mitogen-activated protein kinase/c-Jun N-terminal kinase (MAPK/JNK) pathways are both… 
Review
2004
Review
2004
Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection.
2001
2001
Evaluation of the effects of North Carolina's 0.08% BAC law.
Highly Cited
2001
Highly Cited
2001
Contrasting Effects of IG20 and Its Splice Isoforms, MADD and DENN-SV, on Tumor Necrosis Factor α-induced Apoptosis and Activation of Caspase-8 and -3*
We identified a novel cDNA (IG20) that is homologous to cDNAs encoding a proteindifferentially expressed in normal and neoplastic… 
Highly Cited
1997
Highly Cited
1997
Dynamic Stochastic Models for Decision Making under Time Constraints
This paper introduces the multiattribute dynamic decision model (MADD) to describe both the dynamic and the stochastic nature of… 
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