• Publications
  • Influence
Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.
TLDR
Recent studies related to the molecular mechanisms of the disease pathogenesis and the development of animal models for GD have led to a better understanding of the pathogenesis of GD and GO and have opened up potential new avenues for developing novel treatments.
miR-30 Regulates Mitochondrial Fission through Targeting p53 and the Dynamin-Related Protein-1 Pathway
TLDR
The data reveal a novel model in which a miRNA can regulate apoptosis through targeting the mitochondrial fission machinery, and identify that miR-30 family members can suppress p53 expression.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
TLDR
Findings provide proof-of-principle that PLpro is a viable target for development of antivirals directed against SARS-CoV, and that potent noncovalent cysteine protease inhibitors can be developed with specificity directed toward pathogenic deubiquitinating enzymes without inhibiting host DUBs.
Selective Induction of Dendritic Cells Using Granulocyte Macrophage-Colony Stimulating Factor, But Not fms-Like Tyrosine Kinase Receptor 3-Ligand, Activates Thyroglobulin-Specific CD4+/CD25+ T Cells
TLDR
Results indicate that skewing immune response toward Th2, through selective activation of dendritic cells using GM-CSF, may have therapeutic potential in Th1 dominant autoimmune diseases including Hashimoto’s thyroiditis.
Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
TLDR
Initial results indicate Stem Cell Educator therapy reverses autoimmunity and promotes regeneration of islet β cells, and in individuals with moderate or severe T1D, a single treatment produces lasting improvement in metabolic control.
Regulatory T cells in multiple sclerosis and myasthenia gravis
TLDR
Several strategies of treatment which have been shown to be effective or are proposed as potential therapies to restore the function of various Treg subsets including Tr1, iTr35, nTregs, and iTregs appear promising for treating patients with MS or MG.
Trichloroethene-induced autoimmune response in female MRL +/+ mice.
TLDR
The results suggest that TCE and its metabolite, DCAC, induce and/or accelerate autoimmune responses in female MRL +/+ mice and suggests that this metabolite may be important in the mechanisms leading to TCE-induced autoimmunity.
IL-10-Producing CD4+CD25+ Regulatory T Cells Play a Critical Role in Granulocyte-Macrophage Colony-Stimulating Factor-Induced Suppression of Experimental Autoimmune Thyroiditis1
TLDR
It is shown that GM-CSF can induce dendritic cells (DCs) with a semimature phenotype, an important characteristic of DCs, which are known to play a critical role in the induction and maintenance of regulatory T cells.
Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity.
TLDR
This review provides a summary of recent research pertaining to the role of cytokines in the pathogenesis of AITD with a particular emphasis on the therapeutic applications of cytokine modulation.
...
...