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Loss of Heterozygosity

Known as: LOH, Allelic Loss, Heterozygosity Loss 
A DNA sequence alteration process in which gain, loss, or exchange of DNA results in loss of function of one allele in a diploid cell. This term is… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Gene MutationMutation
HemizygoteLINC00312 geneNeoplastic ProcessesTumor Progression

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicans
ABSTRACT Genetic diversity is often generated during adaptation to stress, and in eukaryotes some of this diversity is thought to… 
Highly Cited
2000
Highly Cited
2000
APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
Although APC mutations occur at a high frequency in colorectal cancers, few studies have performed a comprehensive analysis by… 
Highly Cited
2000
Highly Cited
2000
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
Studies were conducted with the final goal of identifying genes of interest mapping to the chromosome region 16q23.3-24.1, an… 
Highly Cited
1997
Highly Cited
1997
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
The familial melanoma gene (INK4a/MTS1/CDKN2) encodes potent tumor suppressor activity. Although mice null for the ink4a homolog… 
Review
1996
Review
1996
Is human patched the gatekeeper of common skin cancers?
Basal cell carcinoma (BCC) is the most common cancer in humans1. The majority of sporadic BCCs have allelic loss on chromosome… 
Highly Cited
1995
Highly Cited
1995
Allelotype of pancreatic adenocarcinoma using xenograft enrichment.
p53 and MTS1 are known to be mutationally inactivated in pancreatic adenocarcinoma. Other tumor suppressor genes are likely also… 
Highly Cited
1993
Highly Cited
1993
Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer.
We evaluated the prognostic significance of p53 mutations and an allelic loss of chromosome 3p in 71 patients with non-small cell… 
Highly Cited
1993
Highly Cited
1993
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.
The adenovirus E1A proteins form complexes with a group of cellular proteins, including a protein of 130 kD. E1A-associated p130… 
Highly Cited
1992
Highly Cited
1992
Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9
Review
1966
Review
1966
A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura.
cornerstone of the theory of evolution by gradual change is that the rate of A evolution is absolutely limited by the amount of… 
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