Loss of Heterozygosity

Known as: LOH, Allelic Loss, Heterozygosity Loss 
A DNA sequence alteration process in which gain, loss, or exchange of DNA results in loss of function of one allele in a diploid cell. This term is… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… (More)
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Highly Cited
2012
Highly Cited
2012
Background:Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic… (More)
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Highly Cited
2011
Highly Cited
2011
MOTIVATION The ability to detect copy-number variation (CNV) and loss of heterozygosity (LOH) from exome sequencing data extends… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders… (More)
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Highly Cited
2004
Highly Cited
2004
MOTIVATION Oligonucleotide microarrays allow genotyping of thousands of single-nucleotide polymorphisms (SNPs) in parallel… (More)
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Highly Cited
1999
Highly Cited
1999
A PCR strategy is described for global amplification of DNA from a single eukaryotic cell that enables the comprehensive analysis… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) are risk… (More)
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Highly Cited
1996
Highly Cited
1996
Loss of heterozygosity (LOH) was detected in morphologically normal lobules adjacent to breast cancers. The most frequent… (More)
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Highly Cited
1991
Highly Cited
1991
HEPATOCELLULAR carcinoma (HCC) is a prevalent cancer in sub-Saharan Africa and eastern Asia1. Hepatitis B virus and aflatoxins… (More)
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Highly Cited
1988
Highly Cited
1988
Renal cell carcinoma (RCC) and normal kidney tissues have been examined from 34 patients with sporadic, nonhereditary RCC… (More)
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