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Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor… Expand Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired… Expand Epithelial-mesenchymal transitions (EMTs) occur as key steps during embryonic morphogenesis, and are now implicated in the… Expand The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. The novel bi-aryl urea BAY… Expand Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the stages of progression of this… Expand Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets… Expand The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs… Expand The authors are grateful to the members of their laboratories for their contributions to the reviewed studies and for their… Expand Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed… Expand It is proposed that most neoplasms arise from a single cell of origin, and tumor progression results from acquired genetic… Expand