• Publications
  • Influence
Lipoxygenase metabolism: roles in tumor progression and survival
The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation of various biologically active eicosanoids. The expression of these enzymes vary throughout the progression ofExpand
  • 244
  • 17
Cyclooxygenases, prostanoids, and tumor progression
In response to various growth factors, hormones or cytokines, arachidonic acid can be mobilized from phospholipids pools and converted to bioactive eicosanoids through cyclooxygenase (COX),Expand
  • 304
  • 15
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth, metastasis, and angiogenesisExpand
  • 227
  • 10
  • PDF
Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid*
Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions. We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor that displays highExpand
  • 119
  • 10
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissues.
Our laboratory has previously demonstrated that increased malignancy of several histological types of human and animal tumours is associated with increases in their cathepsin B activity, particularlyExpand
  • 378
  • 8
Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium.
PECAM-1 (CD31/EndoCAM) is an adhesion molecule in the immunoglobulin supergene family that is expressed on endothelial cells, platelets, and some hematopoietic lineage cells. In this paper, usingExpand
  • 78
  • 8
The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis
Thromboxane A2 (TXA2) is a biologically active metabolite of arachidonic acid formed by the action of the terminal synthase, thromboxane A2 synthase (TXA2S), on prostaglandin endoperoxide (PGH2).Expand
  • 69
  • 7
Prostacyclin: a potent antimetastatic agent.
Metastasis is the principal cause of failures to cure human cancers. Prostacyclin is a powerful antimetastatic agent against B16 amelanotic melanoma cells. This effect, which may result from theExpand
  • 335
  • 5
Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.
Arachidonic acid (AA) metabolites derived from both cyclooxygenase (COX) and lipoxygenase (LOX) pathways transduce a variety of signals related to cell growth. Here, we report that the AA LOX pathwayExpand
  • 345
  • 5
  • PDF
Interactions of cancer cells with the microvasculature during metastasis 1 2
Metastasis of cancer via the bloodstream is a major factor in the diagnosis, treatment, and prognosis of patients with cancer. Key events in hematogenous metastasis occur in the microvasculature.Expand
  • 178
  • 5