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Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletelyExpand
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Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*
Hypoxia-inducible factor (HIF) is a transcriptional regulator that plays a key role in many aspects of oxygen homeostasis. The heterodimeric HIF complex is regulated by proteolysis of its α-subunits,Expand
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Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade.
PURPOSE A number of microarray studies have reported distinct molecular profiles of breast cancers (BC), such as basal-like, ErbB2-like, and two to three luminal-like subtypes. These were associatedExpand
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Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
ABSTRACT Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor α subunits (HIF-1α and HIF-2α), leading to constitutiveExpand
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Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
Although the role of miR-200s in regulating E-cadherin expression and epithelial-to-mesenchymal transition is well established, their influence on metastatic colonization remains controversial. HereExpand
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Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation.
‘Angiogenesis Group, Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium; *Department of Oncology, St. Bortolo Hospital, Vicenza, Italy; ‘ICRF MolecularExpand
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Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.
PURPOSE To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T cells (TR) in breast cancer patients with long-term follow-up. PATIENTS AND METHODS FOXP3-positive TRExpand
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Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
Cellular microvesicles and nanovesicles (exosomes) are involved in many disease processes and have major potential as biomarkers. However, developments in this area are constrained by limitations inExpand
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REporting recommendations for tumour MARKer prognostic studies (REMARK)
  • A. Harris
  • Medicine
  • British Journal of Cancer
  • 16 August 2005
One of the key ways to translate new basic discoveries into clinical relevance is the analysis of gene expression in tumour samples, relating this to various outcomes. These may include relapse-freeExpand
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Activating transcription factor 4.
  • K. Ameri, A. Harris
  • Biology, Medicine
  • The international journal of biochemistry & cell…
  • 2008
Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip)Expand
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