• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy
These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. Expand
Hypoxia — a key regulatory factor in tumour growth
  • A. Harris
  • Biology, Medicine
  • Nature Reviews Cancer
  • 2002
Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation, angiogenesis and death, and many elements of the hypoxia-response pathway are good candidates for therapeutic targeting. Expand
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.
Gene expression grade index appeared to reclassify patients with histologic grade 2 tumors into two groups with high versus low risks of recurrence, which may improve the accuracy of tumor grading and thus its prognostic value. Expand
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
  • C. Sotiriou, S. Neo, +7 authors E. Liu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 13 August 2003
Gene expression patterns were found to be strongly associated with estrogen receptor (ER) status and moderately associated with grade, but not associated with menopausal status, nodal status, or tumor size, in an unselected group of 99 node-negative and node-positive breast cancer patients. Expand
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
A new class of HIF-1-responsive gene is defined, the activation of which has implications for the understanding of hypoxic tumor metabolism and which may provide endogenous markers for tumor hypoxia. Expand
Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series
This independent validation confirmed the performance of the 76-gene signature and adds to the growing evidence that gene expression signatures are of clinical relevance, especially for identifying patients at high risk of early distant metastases. Expand
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor*
It is shown using suppression by small interference RNA that each of the three PHD isoforms contributes in a non-redundant manner to the regulation of both Hif-1α and HIF-2α subunits and that the contribution of each PHD under particular culture conditions is strongly dependent on the abundance of the enzyme. Expand
Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade.
The use of genomic grade can identify two clinically distinct ER-positive molecular subtypes in a simple and highly reproducible manner across multiple data sets and emphasizes the important role of proliferation-related genes in predicting prognosis in ER- positive BC. Expand
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
HIF-α isoform-specific transcriptional selectivity was matched by differential effects on the growth of RCC as tumor xenografts, with HIF-1α retarding and Hif-2α enhancing tumor growth. Expand
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
A pleiotropic role of miR-200s is suggested in promoting metastatic colonization by influencing E-cadherin–dependent epithelial traits and Sec23a-mediated tumor cell secretome. Expand