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Hepatocellular carcinoma (HCC) is characterized by a propensity for multifocality, growth by local spread, and dysregulation of… Expand The anti-diabetic drug metformin reduces human cancer incidence and improves the survival of cancer patients, including those… Expand Oxidative and electrophilic stresses are sensed by Keap1, which activates Nrf2 to achieve cytoprotection by regulating the… Expand Metformin is used for the treatment of type 2 diabetes because of its ability to lower blood glucose. The effects of metformin… Expand How cyclooxygenase-2 (COX-2) and its proinflammatory metabolite prostaglandin E2 (PGE2) enhance colon cancer progression remains… Expand Whereas the stress-inducible heat-shock protein 70 (Hsp70) has gained plenty of attention as a putative target for tumor therapy… Expand Suberoylanilide hydroxamic acid (SAHA) is a potent inhibitor of histone deacetylases (HDACs) that causes growth arrest… Expand BACKGROUND
The role of dietary components in cancer progression and metastasis is an emerging field of clinical importance. Many… Expand Abstract. Polyamines are aliphatic cations with multiple functions and are essential for life. Cellular polyamine levels are… Expand A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2… Expand