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The distinct morphogenic states of Candida albicans.
The human fungal pathogen, Candida albicans can grow in at least three different morphologies: yeast, pseudohyphae and hyphae. Further morphological forms exist during colony switching, for example,… Expand
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and… Expand
Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicans
Resistance to the limited number of available antifungal drugs is a serious problem in the treatment of Candida albicans. We found that aneuploidy in general and a specific segmental aneuploidy,… Expand
Candida albicans: A molecular revolution built on lessons from budding yeast
Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often… Expand
Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p
- Eric S. Bensen, Samuel J. Martin, M. Li, J. Berman, Dana A. Davis
- Biology, Medicine
- Molecular microbiology
- 1 December 2004
The human pathogen Candida albicans grows and colonizes sites that can vary markedly in pH. The pH response in C. albicans is governed in part by the Rim101p pathway. In Saccharomyces cerevisiae,… Expand
Candida albicans hyphae have a Spitzenkörper that is distinct from the polarisome found in yeast and pseudohyphae
Fungi grow with a variety of morphologies: oval yeast cells, chains of elongated cells called pseudohyphae and long, narrow, tube-like filaments called hyphae. In filamentous fungi, hyphal growth is… Expand
Morphogenesis and cell cycle progression in Candida albicans.
- J. Berman
- Biology, Medicine
- Current opinion in microbiology
- 1 December 2006
Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle… Expand
A Mutation in Tac1p, a Transcription Factor Regulating CDR1 and CDR2, Is Coupled With Loss of Heterozygosity at Chromosome 5 to Mediate Antifungal Resistance in Candida albicans
TAC1, a Candida albicans transcription factor situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole… Expand
Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.
Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC-… Expand
Cassettes for PCR‐mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans
We have developed a set of plasmids containing fluorescent protein cassettes for use in PCR‐mediated gene tagging in Candida albicans. We engineered YFP and CFP variants of the GFP sequence optimized… Expand