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LY2334737

Known as: Gemcitabine Prodrug LY2334737 
An orally available valproic acid prodrug of gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity… Expand
National Institutes of Health

Papers overview

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2018
2018
HighlightsUltra‐sensitive method to quantify gemcitabine and dFdU.Limit of detection of 2.5 pg/mL for gemcitabine and 250 pg/mL… Expand
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2016
2016
Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays… Expand
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2015
2015
SummaryBackground This Phase 1b study aimed to determine the recommended Phase 2 dose of LY2334737, an oral pro-drug of… Expand
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Review
2014
Review
2014
Antimetabolites are the most widely used and most efficacious group of anticancer drugs. Antimetabolites are also the oldest… Expand
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Highly Cited
2013
Highly Cited
2013
Purpose: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for… Expand
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2013
2013
LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice… Expand
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2013
2013
Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an… Expand
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2013
2013
PurposeLY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese… Expand
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2011
2011
Purpose: LY2334737 is an orally available prodrug of gemcitabine. The objective of this study was to determine the maximum… Expand
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2011
2011
Metronomic chemotherapy refers to the close, regular administration of conventional chemotherapy drugs at relatively low… Expand
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