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HighlightsUltra‐sensitive method to quantify gemcitabine and dFdU.Limit of detection of 2.5 pg/mL for gemcitabine and 250 pg/mL… Expand Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the human intestine and various tumour tissues, plays… Expand SummaryBackground This Phase-I-study aimed to determine the recommended Phase-II-dosing-schedule of LY2334737, an oral… Expand Antimetabolites are the most widely used and most efficacious group of anticancer drugs. Antimetabolites are also the oldest… Expand Purpose: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for… Expand LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice… Expand Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an… Expand PurposeLY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese… Expand Purpose: LY2334737 is an orally available prodrug of gemcitabine. The objective of this study was to determine the maximum… Expand Metronomic chemotherapy refers to the close, regular administration of conventional chemotherapy drugs at relatively low… Expand