LY2334737

Known as: Gemcitabine Prodrug LY2334737 
An orally available valproic acid prodrug of gemcitabine, a broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2016
02420092016

Papers overview

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2015
2015
Background This Phase-I-study aimed to determine the recommended Phase-II-dosing-schedule of LY2334737, an oral gemcitabine… (More)
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2015
2015
Background This Phase 1b study aimed to determine the recommended Phase 2 dose of LY2334737, an oral pro-drug of gemcitabine, in… (More)
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2014
2014
This Phase 1 study aimed to determine the recommended Phase 2 dose of LY2334737, an oral gemcitabine prodrug, when combined with… (More)
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2013
2013
PURPOSE The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for… (More)
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2013
2013
LY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese… (More)
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2013
2013
LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice… (More)
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2013
2013
LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice… (More)
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2013
2013
Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an… (More)
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2012
2012
Metronomic chemotherapy refers to the close, regular administration of conventional chemotherapy drugs at relatively low… (More)
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2009
2009
PURPOSE LY2334737 is an orally available prodrug of gemcitabine. The objective of this study was to determine the maximum… (More)
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