S. Pratt

Publications49
h-index16
Citations1,093
Highly Influential Citations46
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • A. Dantzig
  • 76 Publications, 3,809 Citations
  • R. G. Deeley
  • 210 Publications, 20,634 Citations
  • S. Cole
  • 267 Publications, 23,097 Citations
  • J. Starling
  • 88 Publications, 2,702 Citations
  • Publications
  • Influence
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
5′-Fluorouracil (5-FU), used in the treatment of colon and breast cancers, is converted intracellularly to 5′-fluoro-2′-deoxyuridine (5-FUdR) by thymidine phosphorylase and is subsequently… Expand
  • 188
  • 10
  • PDF
Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α MAPK phosphorylates a number of… Expand
  • 80
  • 8
  • PDF
Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in…
Many neoplastic cell lines secrete insulin-like growth factor binding proteins (IGFBPs). The physiological role of these proteins is incompletely characterized; under various conditions IGFBPs have… Expand
  • 126
  • 4
  • PDF
Expression of multidrug resistance‐associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays
Aims: Using tissue microarrays, this study analysed the expression of the multidrug resistance protein, MRP2, by immunohistochemistry with two different MRP2 antibodies. This is the first study to… Expand
  • 110
  • 4
Removing the superior colliculus silences eye movements normally evoked from stimulation of the parietal and occipital eye fields
Abstract After removal of the superior colliculus eye movements could no longer be electrically evoked from striate, prestriate of inferior parietal cortex. However, shifts of gaze induced by frontal… Expand
  • 99
  • 4
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.
Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP,… Expand
  • 49
  • 3
Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug…
Several of the ATP-binding cassette (ABC) transporters confer resistance to anticancer agents and/or antiviral agents when overexpressed in drug-sensitive cells. Recently a MRP1 (ABCC1) tricyclic… Expand
  • 32
  • 3
Efficacy of Low-Dose Oral Metronomic Dosing of the Prodrug of Gemcitabine, LY2334737, in Human Tumor Xenografts
LY2334737, an oral prodrug of gemcitabine, is cleaved in vivo, releasing gemcitabine and valproic acid. Oral dosing of mice results in absorption of intact prodrug with slow systemic hydrolysis… Expand
  • 17
  • 3
Identification and characterization of the canine multidrug resistance-associated protein.
Human multidrug resistance protein 1 (MRP1) confers resistance to the Vinca alkaloids, the anthracyclines, and the epipodophyllotoxins. It is also capable of binding to and transporting the… Expand
  • 23
  • 2
  • PDF
Insulin-like growth factor binding protein 3 (IGF-BP3) inhibits estrogen-stimulated breast cancer cell proliferation.
  • S. Pratt, M. Pollak
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 15 January 1994
We have recently demonstrated that exposure of MCF7 cells to antiestrogens in vitro results in both accumulation of IGF-BP3 in media and reduced mitogenic responsivity to IGFs (Cancer Res.… Expand
  • 73
  • 1