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LTK protein, human

Known as: Protein Tyrosine Kinase 1, leukocyte tyrosine kinase protein, human, Protein Tyrosine Kinase-1 
Leukocyte tyrosine kinase receptor (864 aa, ~92 kDa) is encoded by the human LTK gene. This protein plays a role in tyrosine phosphorylation… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Significance Many cancers (e.g., subpopulations of lung cancer, anaplastic lymphoma, and neuroblastoma) are driven by mutations… Expand
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Review
2013
Review
2013
  • R. Roskoski
  • Pharmacological research
  • 2013
  • Corpus ID: 16912854
Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of… Expand
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Highly Cited
2012
Highly Cited
2012
Anaplastic Lymphoma Kinase (Alk) is a receptor tyrosine kinase expressed throughout the adult mammalian hippocampus. Recent… Expand
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2009
2009
ACK1 (activated Cdc42-associated kinase 1), a cytoplsmic tyrosine kinase, is implicated in metastatic behavior, cell spreading… Expand
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Highly Cited
2008
Highly Cited
2008
A fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells… Expand
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Highly Cited
2006
Highly Cited
2006
4010 Background: Advanced BTC (gallbladder, bile duct) and HCC respond poorly to systemic chemotherapy. Lapatinib is an oral… Expand
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Highly Cited
2005
Highly Cited
2005
Development of distant metastasis after tumor resection is the leading cause of death in early-stage non-small cell lung cancer… Expand
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Highly Cited
2004
Highly Cited
2004
Novel high-throughput analyses in molecular biology allow sensitive and rapid identification of disease-related genes and drug… Expand
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Highly Cited
2003
Highly Cited
2003
Photodynamic therapy (PDT) is a minimally invasive procedure with increasing promise in treatment of malignant and nonmalignant… Expand
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Highly Cited
1997
Highly Cited
1997
Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine… Expand
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