The phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase

@article{Ueno1997TheP3,
  title={The phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase},
  author={Hiroo Ueno and H. Honda and T. Nakamoto and T. Yamagata and K. Sasaki and K. Miyagawa and K. Mitani and Y. Yazaki and H. Hirai},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={3067-3072}
}
  • Hiroo Ueno, H. Honda, +6 authors H. Hirai
  • Published 1997
  • Biology, Medicine
  • Oncogene
  • Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-1 suppresses apoptosis of hematopoietic cells, suggesting the existence of another unidentified signaling pathway downstream of IRS-1, which is relevant to the anti-apoptotic… CONTINUE READING
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