The phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase

@article{Ueno1997TheP3,
  title={The phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase},
  author={Hiroo Ueno and Hiroaki Honda and Tetsuya Nakamoto and Tetsuya Yamagata and Ko Sasaki and Kiyoshi Miyagawa and Kinuko Mitani and Yoshio Yazaki and Hisamaru Hirai},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={3067-3072}
}
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-1 suppresses apoptosis of hematopoietic cells, suggesting the existence of another unidentified signaling pathway downstream of IRS-1, which is relevant to the anti-apoptotic… CONTINUE READING