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LTC4S gene

Known as: LEUKOTRIENE C4 SYNTHASE, LTC4S, MGC33147 
National Institutes of Health

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2 relations
Leukotriene C4leukotriene-C4 synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Type 2 Cysteinyl Leukotriene Receptors Drive IL-33–Dependent Type 2 Immunopathology and Aspirin Sensitivity
Cysteinyl leukotrienes (cysLTs) facilitate mucosal type 2 immunopathology by incompletely understood mechanisms. Aspirin… 
Highly Cited
2016
Highly Cited
2016
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages
Significance We recently uncovered a family of macrophage-derived molecules, coined maresin conjugates in tissue regeneration… 
Review
2015
Review
2015
Factors driving the aspirin exacerbated respiratory disease phenotype
Background Aspirin-exacerbated respiratory disease (AERD) is explained in part by overexpression of 5-lipoxygenase and… 
2013
2013
Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients
Cysteinyl leukotrienes contribute to Th2‐type inflammatory immune responses. Their levels in oesophageal tissue, however, do not… 
Highly Cited
2007
Highly Cited
2007
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
The cysteinyl leukotrienes, namely leukotriene (LT)C4 and its metabolites LTD4 and LTE4, the components of slow-reacting… 
2004
2004
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis
Abstract.Cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contracting agents, which play key roles in inflammatory and… 
Highly Cited
2003
Highly Cited
2003
Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis
Background Cysteinyl leukotrienes (CysLTs) are bioactive lipids that have been shown to contribute to allergic and inflammatory… 
Review
2002
Review
2002
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
Highly Cited
1997
Highly Cited
1997
Site-directed Mutagenesis of Human Leukotriene C4Synthase*
The functional characteristics of leukotriene C4 synthase (LTC4S), which specifically conjugates leukotriene A4 with GSH, were… 
Highly Cited
1994
Highly Cited
1994
Molecular cloning and expression of human leukotriene C4 synthase.
Abstract Leukotriene-C4 synthase (LTC4S; EC 2.5.1.37) catalyzes the committed step in the biosynthesis of the… 
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