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leukotriene-C4 synthase

Known as: LTC4 synthase, leukotriene A4-glutathione S-leukotrienyltransferase, leukotriene C4 synthetase 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

GSTA4 protein, human

Broader (1)

Glutathione S-Transferase
LTC4S gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99
Significance Leukotriene E4 (LTE4), a lipid mediator detected in asthma exacerbations triggered by allergen, viruses, and aspirin… 
Highly Cited
2015
Highly Cited
2015
Lipoxin and resolvin biosynthesis is dependent on 5‐lipoxygenase activating protein
Resolution of acute inflammation is an active process coordinated by proresolving lipid mediators (SPMs) such as lipoxins (LXs… 
2014
2014
Synthesis of leukotrienes in porcine uteri with endometritis induced by infection with Escherichia coli.
Leukotrienes (LTs) are lipid mediators that play a significant role in the inflammatory process. Their production in inflamed… 
Highly Cited
2007
Highly Cited
2007
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
The cysteinyl leukotrienes, namely leukotriene (LT)C4 and its metabolites LTD4 and LTE4, the components of slow-reacting… 
Review
2007
Review
2007
Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation
Kim DC, Hsu FI, Barrett NA, et al. J Immunol. 2006;176:4440–4448 PURPOSE OF THE STUDY. The cysteinyl leukotrienes (cysLTs… 
Review
2007
Review
2007
Treatment heterogeneity in asthma: genetics of response to leukotriene modifiers.
Despite advances in treatment, asthma continues to be a significant health and economic burden. Although asthma cannot be cured… 
Highly Cited
2002
Highly Cited
2002
Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist
Background Treatment with antileukotriene drugs results in clinical improvement in many, though not all, patients with asthma. It… 
Highly Cited
2001
Highly Cited
2001
Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.
Certain immunocompetent myeloid cells, such as eosinophils, basophils and mast cells, have a large capacity to synthesize the… 
Review
1999
Review
1999
The biochemical, molecular, and genomic aspects of leukotriene C4 synthase.
Leukotriene C4 (LTC4) synthase is an 18 kD integral membrane enzyme of the 5-lipoxygenase/LTC4 synthase pathway and is positioned… 
1998
1998
Expression and regulation of leukotriene‐synthesis enzymes in rat liver cells
The liver plays a major role in metabolism and elimination of leukotrienes (LT). It produces cysteinyl leukotrienes (cLT), and… 
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