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Cdc25A is a novel phosphatase functioning early in the cell cycle.
TLDR
Results indicate that cdc25A is not a mitotic regulator but a novel phosphatase that plays a crucial role in the start of the cell cycle. Expand
Cysteinyl Leukotrienes and Their Receptors: Cellular Distribution and Function in Immune and Inflammatory Responses1
TLDR
The functions of cys-LTs and their receptors in the recruitment and activation of effector leukocytes and induction of adaptive immunity; and the development of fibrosis and airway remodeling in animal models of lung injury and allergic inflammation are reviewed. Expand
Neutrophil-derived leukotriene B4 is required for inflammatory arthritis
TLDR
A nonredundant role for LTB4 in inflammatory arthritis is demonstrated and a neutrophil mediator involved in orchestrating the synovial eruption is defined, finding via reconstitution experiments that mast cells are a dispensable source of leukotrienes, whereas arthritis susceptibility can be restored by intravenous administration of wild-type neutrophils. Expand
Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4 Ligand*
TLDR
GPR99 deficiency abolishes LTE4-induced vascular permeability in mice also lacking the two known receptors, indicating GPR99 is a potential third cysteinyl leukotriene receptor and may be a therapeutic target for inflammatory diseases. Expand
Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells1
TLDR
Findings identify the Dectin-2/FcRγ/Syk/cys-LT axis as a novel mechanism by which three potent indoor allergens may activate innate immune cells to promote allergic inflammation. Expand
Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12 receptor
TLDR
The adenosine diphosphate–reactive purinergic (P2Y12) receptor is required for proinflammatory actions of the stable abundant mediator LTE4 and is a novel potential therapeutic target for asthma. Expand
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase
TLDR
The enzyme is the first member of the sigma class glutathione S-transferase (GST) from vertebrates and possesses a prominent cleft as the active site, which is never seen among other members of the GST family. Expand
Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors
TLDR
The findings establish the existence of a third receptor, CysLTER, that responds preferentially to LTE4, the most abundant cys-LT in biologic fluids, and thus reveal a new target for therapeutic intervention. Expand
GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4
TLDR
GPR17 is a ligand-independent, constitutive negative regulator for the type 1 cys-LT receptor that suppresses CysLT1R-mediated function at the cell membrane, suggesting a negative regulatory function of GPR17 for Cys LT1R in a primary cell. Expand
Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator
TLDR
The possibility that a differentiation control system found in the fission yeast might well be conserved in more complex organisms, including mammals is discussed, to suggest a role for ROD1 in differentiation control in mammalian cells. Expand
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