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LIMK1 protein, human

Known as: LIM Domain Kinase 1, LIMK-1 protein, LIM KINASE 
LIM domain kinase 1 (647 aa, ~73 kDa) is encoded by the human LIMK1 gene. This protein is involved in both actin cytoskeleton organization and serine… 
National Institutes of Health

Related topics

Related topics

17 relations
Axon GuidanceCCR3 Signaling PathwayCytoskeletal ModelingEnzyme Gene

Broader (2)

LIM Domain Kinase 1Protein Kinases

Papers overview

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Highly Cited
2011
Highly Cited
2011
Spinoculation Triggers Dynamic Actin and Cofilin Activity That Facilitates HIV-1 Infection of Transformed and Resting CD4 T Cells
ABSTRACT Centrifugal inoculation, or spinoculation, is widely used in virology research to enhance viral infection. However, the… 
Highly Cited
2009
Highly Cited
2009
Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity
Dendritic spines are the postsynaptic sites of most excitatory synapses in the brain and are highly enriched in polymerized F… 
Highly Cited
2009
Highly Cited
2009
Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM Kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth*
Actin cytoskeletal remodeling is essential for neurite outgrowth. LIM kinase 1 (LIMK1) regulates actin cytoskeletal remodeling by… 
Highly Cited
2007
Highly Cited
2007
Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.
Highly Cited
2004
Highly Cited
2004
Caspase‐mediated cleavage and activation of LIM‐kinase 1 and its role in apoptotic membrane blebbing
Actin cytoskeletal reorganization plays a critical role in cell morphological changes, including membrane blebbing during… 
Review
2003
Review
2003
Regulation of Spine Morphology and Synaptic Function by LIMK and the Actin Cytoskeleton
Filamentous actin (F-actin) is highly enriched in the dendritic spine, a specialized postsynaptic structure on which the great… 
Highly Cited
2003
Highly Cited
2003
LIM Kinase 1 Is Essential for the Invasive Growth of Prostate Epithelial Cells
Mammalian LIM kinase 1 (LIMK1) is involved in reorganization of actin cytoskeleton through inactivating phosphorylation of the… 
Highly Cited
2001
Highly Cited
2001
Activation of LIM Kinases by Myotonic Dystrophy Kinase-related Cdc42-binding Kinase α*
LIM kinases (LIMK1 and LIMK2) regulate actin cytoskeletal reorganization through cofilin phosphorylation downstream of distinct… 
Highly Cited
1995
Highly Cited
1995
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family.
We previously isolated human cDNA encoding LIM-kinase (LIMK), a putative protein kinase which contains two repeats of the LIM… 
Highly Cited
1995
Highly Cited
1995
Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro.
We have isolated the murine Limk1 gene, which is a single copy gene located at the distal end of mouse chromosome 5. Limk1… 
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