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A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes.
Monocyte-derived myeloid cells play vital roles in inflammation-related autoimmune/inflammatory diseases and cancers. Here, we report that exosomes can deliver anti-inflammatory agents, such asExpand
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Induction of myeloid‐derived suppressor cells by tumor exosomes
Myeloid‐derived suppressor cells (MDSCs) promote tumor progression. The mechanisms of MDSC development during tumor growth remain unknown. Tumor exosomes (T‐exosomes) have been implicated to play aExpand
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Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells1
The production of exosomes by tumor cells has been implicated in tumor-associated immune suppression. In this study, we show that, in mice, exosomes produced by TS/A murine mammary tumor cells targetExpand
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Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
OBJECTIVE We sought to determine whether exosome-like vesicles (ELVs) released from adipose tissue play a role in activation of macrophages and subsequent development of insulin resistance in a mouseExpand
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Nuclear Localization of KLF4 Is Associated with an Aggressive Phenotype in Early-Stage Breast Cancer
Purpose: The Krüppel-like transcription factor KLF4/GKLF induces both malignant transformation and a slow-growth phenotype in vitro. Although KLF4 expression is increased in most cases of breastExpand
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Modern age pathology of pulmonary arterial hypertension
  • Elvira Stacher, Elvira Stacher, +8 authors R. Tuder
  • Medicine
  • ATS
  • 1 September 2012
Introduction: The impact of modern treatments of pulmonary arterial hypertension (PAH) on pulmonary vascular pathology remains unknown. The last series reporting the pathology of severe pulmonaryExpand
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Recurrent read-through fusion transcripts in breast cancer
Read-through fusion transcripts that result from the splicing of two adjacent genes in the same coding orientation are a recently discovered type of chimeric RNA. We sought to determine ifExpand
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Increase of GKLF messenger RNA and protein expression during progression of breast cancer.
Genetic alterations found in carcinomas can alter specific regulatory pathways and provide a selective growth advantage by activation of transforming oncogenes. A subset of these genes, includingExpand
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Serum Biomarker Panels for the Detection of Pancreatic Cancer
Purpose: Serum–biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations. Experimental Design: Eighty-three circulating proteinsExpand
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Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human malignancies, with an overall 5-year survival rate of <5%. Genetic analysis of PDAC patient samples has shown that specificExpand
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