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Neurotrophins: roles in neuronal development and function.
Neurotrophins regulate development, maintenance, and function of vertebrate nervous systems, and control synaptic function and synaptic plasticity, while continuing to modulate neuronal survival. Expand
Neurotrophin-regulated signalling pathways
  • L. Reichardt
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B…
  • 29 September 2006
Three rare human genetic disorders, which result in deleterious effects on sensory perception, cognition and a variety of behaviours, have been shown to be attributable to mutations in brain-derived neurotrophic factor and two of the Trk receptors. Expand
Trk receptors: roles in neuronal signal transduction.
The most fascinating aspect of Trk receptor-mediated signaling is its interplay with signaling promoted by the pan-neurotrophin receptor p75NTR, which activates a distinct set of signaling pathways within cells that are in some instances synergistic and in other instances antagonistic to those activated by Trk receptors. Expand
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
It is reported that BDNF is expressed at high levels in the ventromedial hypothalamus (VMH) where its expression is regulated by nutritional state and by MC4R signaling, and this results show that MC 4R signaling controls BDNF expression in the VMH. Expand
Trk receptors: mediators of neurotrophin action
Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophIn signaling, where key intermediates are localized to different membrane compartments. Expand
Renal and neuronal abnormalities in mice lacking GDNF
It is shown that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons, and GDNF is important for the development and/or survival of enteric, sympathetic, and sensory neurons and the renal system, but is not essential for catecholaminergic neuron in the central nervous system (CNS). Expand
Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons
Results show that trkA‐expressing cells in dorsal root ganglia correspond almost exactly with the CGRP, peptide‐producing population, and the receptor is present not only on cell bodies but also on central terminals. Expand
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
It is reported that mice lacking neurotrophin-3 have severe deficits in sensory and sympathetic populations and motor neurons, the enteric nervous system, and the major anatomical regions of the central nervous system seem to develop normally. Expand
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
The BDNF mutant homozygotes have substantially reduced numbers of cranial and spinal sensory neurons and expression of neuropeptide Y and calcium-binding proteins is altered in many neurons, suggesting they do not function normally. Expand
GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney
Findings support the idea that GFRalpha1 and the transmembrane tyrosine kinase Ret are both necessary receptor components for GDNF in the developing kidney and nervous system, and that GDNF and neurturin can mediate some of their activities through a second receptor. Expand