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Regulation of HDM2 activity by the ribosomal protein L11.
The HDM2 protein plays an important role in regulating the stability and function of the p53 tumor suppressor protein. In this report, we show that the ribosomal protein L11 can interact with HDM2Expand
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p14ARF links the tumour suppressors RB and p53
Most human cancers show perturbation of growth regulation mediated by the tumour-suppressor proteins retinoblastoma (RB) and p53 (ref. 1), indicating that loss of both pathways is necessary forExpand
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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*
Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its activity isExpand
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Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in aExpand
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Mutant p53 Drives Invasion by Promoting Integrin Recycling
p53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 proteins that haveExpand
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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells.
The p53 tumor suppressor protein is regulated by its interaction with HDM2, which serves as a ubiquitin ligase (E3) to target p53 for degradation. We have identified a family of small moleculesExpand
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Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.
The p53 tumor‐suppressor gene product is frequently inactivated in malignancies by point mutation. Although most tumor‐derived p53 mutants show loss of sequence specific transcriptional activation,Expand
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Regulation of Mdm2-Directed Degradation by the C Terminus of p53
ABSTRACT The stability of the p53 tumor suppressor protein is regulated by interaction with Mdm2, the product of a p53-inducible gene. Mdm2-targeted degradation of p53 depends on the interactionExpand
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Phosphorylation of HDM2 by Akt
The HDM2 protein is a key regulator of the tumour suppressor, p53. Control of HDM2 function is critical for normal cell proliferation and stress responses, and it is becoming evident that multipleExpand
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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
The p53-inducible protein TIGAR (Tp53-induced Glycolysis and Apoptosis Regulator) functions as a fructose-2,6-bisphosphatase (Fru-2,6-BPase), and through promotion of the pentose phosphate pathway,Expand
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