LIM Domain Kinase 1

Known as: LIM-Kinase, Lim Kinases, LIM Motif-Containing Protein Kinases 
Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2018
010203019822018

Papers overview

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Highly Cited
2005
Highly Cited
2005
Slingshot (SSH) phosphatases and LIM kinases (LIMK) regulate actin dynamics via a reversible phosphorylation (inactivation) of… (More)
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Highly Cited
2005
Highly Cited
2005
Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge… (More)
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Highly Cited
2003
Highly Cited
2003
p57Kip2 is the only cyclin-dependent kinase (Cdk) inhibitor shown to be essential for mouse embryogenesis. The fact suggests that… (More)
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Highly Cited
2001
Highly Cited
2001
Semaphorin 3A is a chemorepulsive axonal guidance molecule that depolymerizes the actin cytoskeleton and collapses growth cones… (More)
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Highly Cited
2001
Highly Cited
2001
LIM-kinase 1 (LIMK1) and LIM-kinase 2 (LIMK2) regulate actin cytoskeletal reorganization via cofilin phosphorylation downstream… (More)
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Highly Cited
2000
Highly Cited
2000
LIM-kinase 1 (LIMK1) phosphorylates cofilin, an actin-depolymerizing factor, and regulates actin cytoskeletal reorganization… (More)
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Highly Cited
1999
Highly Cited
1999
Extracellular signals regulate actin dynamics through small GTPases of the Rho/Rac/Cdc42 (p21) family. Here we show that p21… (More)
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Highly Cited
1999
Highly Cited
1999
The actin cytoskeleton undergoes extensive remodeling during cell morphogenesis and motility. The small guanosine triphosphatase… (More)
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Highly Cited
1998
Highly Cited
1998
Rac is a small GTPase of the Rho family that mediates stimulus-induced actin cytoskeletal reorganization to generate lamellipodia… (More)
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Highly Cited
1998
Highly Cited
1998
Cell division, cell motility and the formation and maintenance of specialized structures in differentiated cells depend directly… (More)
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